Detailed information of TA system TA021550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 463712..464385
• Replicon: chromosome
• Accession: NC_007953
• Organism: Burkholderia xenovorans LB400

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BXE_RS38775
• Protein ID: WP_011493602.1
• Coordinates: 463712..464116 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BXE_RS38780
• Protein ID: WP_040123745.1
• Coordinates: 464113..464385 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXE_RS38750	459029..460444	+	1416	WP_011493596.1	amidase	-
BXE_RS38755	460441..460986	+	546	WP_011493597.1	amino acid synthesis family protein	-
BXE_RS38760	461060..462094	+	1035	WP_011493598.1	porin	-
BXE_RS46795	462241..462411	-	171	WP_158340964.1	hypothetical protein	-
BXE_RS38765	462732..462974	+	243	WP_011493600.1	AlpA family phage regulatory protein	-
BXE_RS38770	462971..463297	+	327	WP_040123546.1	hypothetical protein	-
BXE_RS38775	463712..464116	-	405	WP_011493602.1	type II toxin-antitoxin system VapC family toxin	Toxin
BXE_RS38780	464113..464385	-	273	WP_040123745.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BXE_RS44975	464684..465262	+	579	WP_148223096.1	hypothetical protein	-
BXE_RS38790	466115..466975	+	861	WP_011493605.1	cobyric acid synthase CobQ	-
BXE_RS38795	466968..467546	+	579	WP_011493606.1	hypothetical protein	-
BXE_RS38800	467543..468190	+	648	WP_011493607.1	lytic transglycosylase domain-containing protein	-
BXE_RS38805	468226..468561	+	336	WP_011493608.1	TrbC/VirB2 family protein	-
BXE_RS38810	468587..468907	+	321	WP_040123545.1	VirB3 family type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	433528..477358	43830

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14408.62 Da
• Isoelectric Point: 4.8604

>T21550 WP_011493602.1 NC_007953:c464116-463712 [Paraburkholderia xenovorans LB400]
MSGYLLDTNIISDMIRNPFGQVAARIEQIDPRAICTSVVVAAELRYGCAKKGSAKLLARVESLLATIPVLPLDVPADTEY
GGIRAELEAAGQPIGANDLLIGAHAYALGLTLVTDNTKEFSRIRGLTIENWLDR

Nucleotide

• Length: 405 bp

>T21550 NC_007953:c464116-463712 [Paraburkholderia xenovorans LB400]
TTGAGCGGCTATCTGCTCGACACGAACATCATCAGCGACATGATCCGGAATCCGTTCGGACAGGTGGCCGCCCGTATTGA
GCAGATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCAAAAAAGGGGTCCG
CGAAGTTGCTGGCCAGAGTCGAAAGTCTCCTTGCAACCATTCCCGTGCTGCCGCTGGACGTCCCTGCCGACACGGAATAC
GGGGGCATCCGCGCGGAGCTTGAGGCCGCCGGCCAGCCGATCGGTGCAAACGACCTTTTGATTGGCGCTCATGCCTACGC
ATTGGGGCTGACACTCGTGACTGACAACACGAAAGAGTTCAGCCGCATTCGCGGTCTCACGATCGAGAACTGGCTTGACC
GGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10258.72 Da
• Isoelectric Point: 4.6677

>AT21550 WP_040123745.1 NC_007953:c464385-464113 [Paraburkholderia xenovorans LB400]
VPIPTPSARPREARLFRNNRSQAVRIPVEFELPGDRVLIHREGDKLIIEPVRTPANIIELLAAWRQELPPGPDDQFPDIE
DPPVRPEDVL

Nucleotide

• Length: 273 bp

>AT21550 NC_007953:c464385-464113 [Paraburkholderia xenovorans LB400]
GTGCCAATCCCAACGCCATCCGCCCGGCCCAGGGAGGCCAGGCTGTTCCGCAACAACCGCAGCCAGGCGGTACGCATCCC
TGTCGAGTTCGAGCTGCCGGGCGATCGCGTTCTGATCCACCGGGAGGGCGACAAGCTCATCATCGAACCGGTGAGGACGC
CCGCGAACATCATCGAACTGCTCGCCGCGTGGAGACAGGAGCTGCCGCCCGGACCTGATGACCAGTTTCCGGATATCGAA
GATCCGCCAGTTCGACCGGAGGACGTACTTTGA