Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 653124..653604 | Replicon | chromosome |
| Accession | NZ_CP082885 | ||
| Organism | Bartonella henselae strain FDAARGOS_1462 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A067WDE7 |
| Locus tag | K8O99_RS02975 | Protein ID | WP_011180622.1 |
| Coordinates | 653335..653604 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | N6VJG4 |
| Locus tag | K8O99_RS02970 | Protein ID | WP_007346764.1 |
| Coordinates | 653124..653351 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8O99_RS02925 (K8O99_02945) | 648271..649521 | + | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| K8O99_RS02930 (K8O99_02950) | 649442..649891 | + | 450 | WP_223396434.1 | hypothetical protein | - |
| K8O99_RS02935 (K8O99_02955) | 650073..650390 | + | 318 | Protein_575 | hypothetical protein | - |
| K8O99_RS02940 (K8O99_02960) | 650581..650853 | - | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| K8O99_RS02945 (K8O99_02965) | 650850..651140 | - | 291 | WP_011180616.1 | hypothetical protein | - |
| K8O99_RS02950 (K8O99_02970) | 651352..651798 | + | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| K8O99_RS02955 (K8O99_02975) | 651852..652346 | + | 495 | WP_059443338.1 | hypothetical protein | - |
| K8O99_RS02960 (K8O99_02980) | 652427..652684 | + | 258 | WP_034448603.1 | antitoxin | - |
| K8O99_RS02965 (K8O99_02985) | 652684..653016 | + | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| K8O99_RS02970 (K8O99_02990) | 653124..653351 | + | 228 | WP_007346764.1 | DUF6290 family protein | Antitoxin |
| K8O99_RS02975 (K8O99_02995) | 653335..653604 | + | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K8O99_RS02980 | 653634..654026 | - | 393 | WP_075320637.1 | hypothetical protein | - |
| K8O99_RS02985 (K8O99_03000) | 654122..654580 | - | 459 | WP_011180624.1 | hypothetical protein | - |
| K8O99_RS02990 (K8O99_03005) | 654879..655205 | + | 327 | WP_011180626.1 | hypothetical protein | - |
| K8O99_RS02995 (K8O99_03010) | 655186..656511 | + | 1326 | WP_011180823.1 | phage terminase large subunit | - |
| K8O99_RS03000 (K8O99_03015) | 656496..658550 | + | 2055 | WP_011180822.1 | portal protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 637032..683978 | 46946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10495.44 Da Isoelectric Point: 10.2009
>T215498 WP_011180622.1 NZ_CP082885:653335-653604 [Bartonella henselae]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAV
GHRKNIYKG
Download Length: 270 bp
>T215498 NZ_CP110790:3617077-3617280 [Yersinia massiliensis]
ATGACTAAAACTGACTACCTGATGCGTTTAAGAAAGTGTACGACTATTGACACGCTTGAGCGTGTAATTGAAAAAAATAA
ATATGAACTTTCTGACGATGAGTTGGAGTTATTCTACTCAGCAGCCGATCATCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTAAAATAG
ATGACTAAAACTGACTACCTGATGCGTTTAAGAAAGTGTACGACTATTGACACGCTTGAGCGTGTAATTGAAAAAAATAA
ATATGAACTTTCTGACGATGAGTTGGAGTTATTCTACTCAGCAGCCGATCATCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTAAAATAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8742.78 Da Isoelectric Point: 4.8780
>AT215498 WP_007346764.1 NZ_CP082885:653124-653351 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD
Download Length: 228 bp
>AT215498 NZ_CP110790:3616661-3617029 [Yersinia massiliensis]
ATGGATGAGTACTCGCCAAAAAGGCATGATATTGCCCAACTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGTATTGC
TACGCTCGGCGATAGCCATCATGGGTGGGTGAACGACCCCACAGCAGCTGTCAATCTGCAACTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCAGACGACGGCGACCTATCAGAGCTAGTGGAAGAATATTTA
GACGATACTTATACTCTGTTTAGTAGTTACGGGATCAACGATCCCGAATTGCGTCGCTGGCAAAAAGCTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACGCTGATGAAAAGTTAA
ATGGATGAGTACTCGCCAAAAAGGCATGATATTGCCCAACTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGTATTGC
TACGCTCGGCGATAGCCATCATGGGTGGGTGAACGACCCCACAGCAGCTGTCAATCTGCAACTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCAGACGACGGCGACCTATCAGAGCTAGTGGAAGAATATTTA
GACGATACTTATACTCTGTTTAGTAGTTACGGGATCAACGATCCCGAATTGCGTCGCTGGCAAAAAGCTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACGCTGATGAAAAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067WDE7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N6VJG4 |