Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 652427..653016 Replicon chromosome
Accession NZ_CP082885
Organism Bartonella henselae strain FDAARGOS_1462

Toxin (Protein)


Gene name pemK Uniprot ID X5M710
Locus tag K8O99_RS02965 Protein ID WP_011180620.1
Coordinates 652684..653016 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A829Z4P4
Locus tag K8O99_RS02960 Protein ID WP_034448603.1
Coordinates 652427..652684 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O99_RS02920 (K8O99_02940) 647802..648281 + 480 WP_011180611.1 hypothetical protein -
K8O99_RS02925 (K8O99_02945) 648271..649521 + 1251 WP_011180612.1 DUF1376 domain-containing protein -
K8O99_RS02930 (K8O99_02950) 649442..649891 + 450 WP_223396434.1 hypothetical protein -
K8O99_RS02935 (K8O99_02955) 650073..650390 + 318 Protein_575 hypothetical protein -
K8O99_RS02940 (K8O99_02960) 650581..650853 - 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
K8O99_RS02945 (K8O99_02965) 650850..651140 - 291 WP_011180616.1 hypothetical protein -
K8O99_RS02950 (K8O99_02970) 651352..651798 + 447 WP_011180617.1 single-stranded DNA-binding protein -
K8O99_RS02955 (K8O99_02975) 651852..652346 + 495 WP_059443338.1 hypothetical protein -
K8O99_RS02960 (K8O99_02980) 652427..652684 + 258 WP_034448603.1 antitoxin Antitoxin
K8O99_RS02965 (K8O99_02985) 652684..653016 + 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K8O99_RS02970 (K8O99_02990) 653124..653351 + 228 WP_007346764.1 DUF6290 family protein -
K8O99_RS02975 (K8O99_02995) 653335..653604 + 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8O99_RS02980 653634..654026 - 393 WP_075320637.1 hypothetical protein -
K8O99_RS02985 (K8O99_03000) 654122..654580 - 459 WP_011180624.1 hypothetical protein -
K8O99_RS02990 (K8O99_03005) 654879..655205 + 327 WP_011180626.1 hypothetical protein -
K8O99_RS02995 (K8O99_03010) 655186..656511 + 1326 WP_011180823.1 phage terminase large subunit -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 637032..683978 46946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-108)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 11865.88 Da        Isoelectric Point: 10.5590

>T215496 WP_011180620.1 NZ_CP082885:652684-653016 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT

Download         Length: 333 bp

>T215496 NZ_CP110790:2172624-2172716 [Yersinia massiliensis]
TAAGCCTACGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGTAT
TCGGTCTTTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9381.71 Da        Isoelectric Point: 4.2101

>AT215496 WP_034448603.1 NZ_CP082885:652427-652684 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL

Download         Length: 258 bp

>AT215496 NZ_CP110790:c2172724-2172605 [Yersinia massiliensis]
AACACGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAACGTAGGCTTACTCAGCCGTACCCTTTAAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A067W4K9


Antitoxin

Source ID Structure
AlphaFold DB A0A829Z4P4

References