Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 652427..653016 | Replicon | chromosome |
Accession | NZ_CP082885 | ||
Organism | Bartonella henselae strain FDAARGOS_1462 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | X5M710 |
Locus tag | K8O99_RS02965 | Protein ID | WP_011180620.1 |
Coordinates | 652684..653016 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A829Z4P4 |
Locus tag | K8O99_RS02960 | Protein ID | WP_034448603.1 |
Coordinates | 652427..652684 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8O99_RS02920 (K8O99_02940) | 647802..648281 | + | 480 | WP_011180611.1 | hypothetical protein | - |
K8O99_RS02925 (K8O99_02945) | 648271..649521 | + | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
K8O99_RS02930 (K8O99_02950) | 649442..649891 | + | 450 | WP_223396434.1 | hypothetical protein | - |
K8O99_RS02935 (K8O99_02955) | 650073..650390 | + | 318 | Protein_575 | hypothetical protein | - |
K8O99_RS02940 (K8O99_02960) | 650581..650853 | - | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
K8O99_RS02945 (K8O99_02965) | 650850..651140 | - | 291 | WP_011180616.1 | hypothetical protein | - |
K8O99_RS02950 (K8O99_02970) | 651352..651798 | + | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
K8O99_RS02955 (K8O99_02975) | 651852..652346 | + | 495 | WP_059443338.1 | hypothetical protein | - |
K8O99_RS02960 (K8O99_02980) | 652427..652684 | + | 258 | WP_034448603.1 | antitoxin | Antitoxin |
K8O99_RS02965 (K8O99_02985) | 652684..653016 | + | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
K8O99_RS02970 (K8O99_02990) | 653124..653351 | + | 228 | WP_007346764.1 | DUF6290 family protein | - |
K8O99_RS02975 (K8O99_02995) | 653335..653604 | + | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
K8O99_RS02980 | 653634..654026 | - | 393 | WP_075320637.1 | hypothetical protein | - |
K8O99_RS02985 (K8O99_03000) | 654122..654580 | - | 459 | WP_011180624.1 | hypothetical protein | - |
K8O99_RS02990 (K8O99_03005) | 654879..655205 | + | 327 | WP_011180626.1 | hypothetical protein | - |
K8O99_RS02995 (K8O99_03010) | 655186..656511 | + | 1326 | WP_011180823.1 | phage terminase large subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 637032..683978 | 46946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11865.88 Da Isoelectric Point: 10.5590
>T215496 WP_011180620.1 NZ_CP082885:652684-653016 [Bartonella henselae]
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
MKRGEIWLVSLDPTSGYEQKGTRPVLIVSPEAFNRVTKTPIVLPITSGGNFSRTAGFAVSLVGTGLHTTGVIRCDQPRAL
DIAARQGKKMETVPPIIMNEVLAKLSTFLT
Download Length: 333 bp
>T215496 NZ_CP110790:2172624-2172716 [Yersinia massiliensis]
TAAGCCTACGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGTAT
TCGGTCTTTTTTT
TAAGCCTACGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATCGTAT
TCGGTCTTTTTTT
Antitoxin
Download Length: 86 a.a. Molecular weight: 9381.71 Da Isoelectric Point: 4.2101
>AT215496 WP_034448603.1 NZ_CP082885:652427-652684 [Bartonella henselae]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
MHTTKLRKVGGSVMLSIPPALLDVLHLTENTQVGLAVDNGQLVVKPQTFPSYTLDELLAQCNPSDDFADEDMEWFDAKPV
GRELL
Download Length: 258 bp
>AT215496 NZ_CP110790:c2172724-2172605 [Yersinia massiliensis]
AACACGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAACGTAGGCTTACTCAGCCGTACCCTTTAAG
AACACGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAACGTAGGCTTACTCAGCCGTACCCTTTAAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A067W4K9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829Z4P4 |