Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-parD/RelE-RHH |
| Location | 650581..651140 | Replicon | chromosome |
| Accession | NZ_CP082885 | ||
| Organism | Bartonella henselae strain FDAARGOS_1462 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M706 |
| Locus tag | K8O99_RS02940 | Protein ID | WP_011180615.1 |
| Coordinates | 650581..650853 (-) | Length | 91 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | X5LVL8 |
| Locus tag | K8O99_RS02945 | Protein ID | WP_011180616.1 |
| Coordinates | 650850..651140 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8O99_RS02900 (K8O99_02920) | 645905..646279 | - | 375 | WP_011180607.1 | hypothetical protein | - |
| K8O99_RS02905 (K8O99_02925) | 646518..646856 | - | 339 | WP_011180608.1 | helix-turn-helix transcriptional regulator | - |
| K8O99_RS02910 | 646941..647303 | + | 363 | WP_034459412.1 | hypothetical protein | - |
| K8O99_RS02915 (K8O99_02935) | 647306..647665 | + | 360 | WP_011180610.1 | hypothetical protein | - |
| K8O99_RS02920 (K8O99_02940) | 647802..648281 | + | 480 | WP_011180611.1 | hypothetical protein | - |
| K8O99_RS02925 (K8O99_02945) | 648271..649521 | + | 1251 | WP_011180612.1 | DUF1376 domain-containing protein | - |
| K8O99_RS02930 (K8O99_02950) | 649442..649891 | + | 450 | WP_223396434.1 | hypothetical protein | - |
| K8O99_RS02935 (K8O99_02955) | 650073..650390 | + | 318 | Protein_575 | hypothetical protein | - |
| K8O99_RS02940 (K8O99_02960) | 650581..650853 | - | 273 | WP_011180615.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| K8O99_RS02945 (K8O99_02965) | 650850..651140 | - | 291 | WP_011180616.1 | hypothetical protein | Antitoxin |
| K8O99_RS02950 (K8O99_02970) | 651352..651798 | + | 447 | WP_011180617.1 | single-stranded DNA-binding protein | - |
| K8O99_RS02955 (K8O99_02975) | 651852..652346 | + | 495 | WP_059443338.1 | hypothetical protein | - |
| K8O99_RS02960 (K8O99_02980) | 652427..652684 | + | 258 | WP_034448603.1 | antitoxin | - |
| K8O99_RS02965 (K8O99_02985) | 652684..653016 | + | 333 | WP_011180620.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| K8O99_RS02970 (K8O99_02990) | 653124..653351 | + | 228 | WP_007346764.1 | DUF6290 family protein | - |
| K8O99_RS02975 (K8O99_02995) | 653335..653604 | + | 270 | WP_011180622.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K8O99_RS02980 | 653634..654026 | - | 393 | WP_075320637.1 | hypothetical protein | - |
| K8O99_RS02985 (K8O99_03000) | 654122..654580 | - | 459 | WP_011180624.1 | hypothetical protein | - |
| K8O99_RS02990 (K8O99_03005) | 654879..655205 | + | 327 | WP_011180626.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 637032..683978 | 46946 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10747.75 Da Isoelectric Point: 11.3976
>T215495 WP_011180615.1 NZ_CP082885:c650853-650581 [Bartonella henselae]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP
Download Length: 273 bp
>T215495 NZ_CP110790:1530168-1530500 [Yersinia massiliensis]
ATGGATGCTGTATTTATTGAATTGCCACCATTTGAACGCGTTAGATTAGATTACTTATCAGACGATGATTATCGAACCTT
GCAGACTGCATTAATGAATAACCCAACGGTTGGAGATGTTATTCAACAAACTGGCGGTTTGCGCAAAATGCGATTCAGTG
AGGCGAAAACAGGGAAGGGCAAGCGTAGTGGTGTCAGAGTCATTTATTATTGGTGGGTCGAGCGTTTTCAGTTTTTGCTC
TTCACCATTTATAGCAAAGGTGAGATGTCTGACTTAACCCATTCGCAGCGGAAAATACTGAGTAATCTTCTTAAGTCCCG
TAAATCTGAATGA
ATGGATGCTGTATTTATTGAATTGCCACCATTTGAACGCGTTAGATTAGATTACTTATCAGACGATGATTATCGAACCTT
GCAGACTGCATTAATGAATAACCCAACGGTTGGAGATGTTATTCAACAAACTGGCGGTTTGCGCAAAATGCGATTCAGTG
AGGCGAAAACAGGGAAGGGCAAGCGTAGTGGTGTCAGAGTCATTTATTATTGGTGGGTCGAGCGTTTTCAGTTTTTGCTC
TTCACCATTTATAGCAAAGGTGAGATGTCTGACTTAACCCATTCGCAGCGGAAAATACTGAGTAATCTTCTTAAGTCCCG
TAAATCTGAATGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 11099.43 Da Isoelectric Point: 4.5837
>AT215495 WP_011180616.1 NZ_CP082885:c651140-650850 [Bartonella henselae]
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS
Download Length: 291 bp
>AT215495 NZ_CP110790:1530519-1530839 [Yersinia massiliensis]
ATGAAAAAAAGAGATTTATTTTCAGAATTGGTTGAGGGAATGGAAGCGTGGGGAGAGGCAAATACGGGAAAGAAGACACT
GAAAACCCACAAAGTCTCGACTGAGAATACCGTGACCCTGACGTCAGAAGAATTACGGCACATCCGTGAAACACTGAATA
TTTCGCAGGCGCTATTTGCGCATTACTTGCAGGCGGGTATTGCAACTTACCAGAATTGGGAGCAAGGCCGAGCCAAACCC
AATAAGCAGGCTATCTTACTGATTAAAATGGTACAAAAAGATCCCCATACACTGCATACGCTCGCTGAACTGTACGAATG
A
ATGAAAAAAAGAGATTTATTTTCAGAATTGGTTGAGGGAATGGAAGCGTGGGGAGAGGCAAATACGGGAAAGAAGACACT
GAAAACCCACAAAGTCTCGACTGAGAATACCGTGACCCTGACGTCAGAAGAATTACGGCACATCCGTGAAACACTGAATA
TTTCGCAGGCGCTATTTGCGCATTACTTGCAGGCGGGTATTGCAACTTACCAGAATTGGGAGCAAGGCCGAGCCAAACCC
AATAAGCAGGCTATCTTACTGATTAAAATGGTACAAAAAGATCCCCATACACTGCATACGCTCGCTGAACTGTACGAATG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W4L5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067W521 |