Detailed information of TA system TA215494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 618688..619167
• Replicon: chromosome
• Accession: NZ_CP082885
• Organism: Bartonella henselae strain FDAARGOS_1462

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K8O99_RS02755
• Protein ID: WP_236087019.1
• Coordinates: 619015..619167 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A829YZI5
• Locus tag: K8O99_RS02750
• Protein ID: WP_034447857.1
• Coordinates: 618688..618915 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O99_RS02705 (K8O99_02715)	613884..614573	+	690	WP_011180829.1	DnaA regulatory inactivator HdaA	-
K8O99_RS02715 (K8O99_02725)	615567..615872	+	306	WP_011180828.1	ETC complex I subunit	-
K8O99_RS02725 (K8O99_02735)	616447..616773	+	327	WP_011180827.1	hypothetical protein	-
K8O99_RS02730 (K8O99_02740)	616815..617108	-	294	WP_034447441.1	HigA family addiction module antitoxin	-
K8O99_RS02735 (K8O99_02745)	617125..617406	-	282	WP_011180826.1	type II toxin-antitoxin system RelE/ParE family toxin	-
K8O99_RS02740 (K8O99_02750)	617597..618043	+	447	WP_011180617.1	single-stranded DNA-binding protein	-
K8O99_RS02745 (K8O99_02755)	618097..618591	+	495	WP_011180825.1	hypothetical protein	-
K8O99_RS02750 (K8O99_02760)	618688..618915	+	228	WP_034447857.1	DUF6290 family protein	Antitoxin
K8O99_RS02755 (K8O99_02765)	619015..619167	+	153	WP_236087019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8O99_RS02760	619197..619589	-	393	WP_223396448.1	hypothetical protein	-
K8O99_RS02765 (K8O99_02770)	619685..620143	-	459	WP_011180624.1	hypothetical protein	-
K8O99_RS02770 (K8O99_02775)	620442..620768	+	327	WP_011180626.1	hypothetical protein	-
K8O99_RS02775 (K8O99_02780)	620749..621888	+	1140	WP_049784545.1	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-48)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5819.95 Da
• Isoelectric Point: 10.3747

>T215494 WP_236087019.1 NZ_CP082885:619015-619167 [Bartonella henselae]
VRVIGKPLKGQFSGLWRYRVGDYRILCELYDKELVVLVLAVGHRKNIYKG

Nucleotide

• Length: 153 bp

>T215494 NZ_CP110790:1036073-1036498 [Yersinia massiliensis]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTTTTCTCTTTATTGACACATGGCGTCTTGGTCAT
CCTCACACTGGTCGCACCTTGGCCTCAGGGTTATACCGCGCTGTGGTTAGTATTGCTGACGCTGGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAGAATATTACCTCCTGCCAAGGGGAGATCCGGCTGAAACCCGGCAATGTGGTGCTATGGAAACGGCTT
GAATGGATTGTCGTTAAGCAGCCATGGATGACCCGATATGGCGTGTTATTGCGCTTACGGCAGGCAAACAGTCGATCAAC
CTGTAAGCGCCTATGGCTGGCGGCTGATAGCATGTCAGAAGATGAGTGGCGGCAACTTTGCTTGCTATTGCGTCACTCCT
TTGATGCGGATGAAGGGCATACCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8714.77 Da
• Isoelectric Point: 4.8780

>AT215494 WP_034447857.1 NZ_CP082885:618688-618915 [Bartonella henselae]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRKGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT215494 NZ_CP110790:1035826-1036092 [Yersinia massiliensis]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTGGATATCTCCATCATGCCATT
TTTTGAATACGAATATGATGGCTTGAGTGATAGCGAGAAGCAGATTTTTATTCGGCTACTGGAATGTGATGACCCAGACC
TTTTCAATTGGCTGATGAATCATGGGGAGCCGCAGGATGACGAACTGCGTCAGATGGTGAAATTGATTCAAACGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A829YZI5