Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 213326..213918 | Replicon | chromosome |
| Accession | NZ_CP082885 | ||
| Organism | Bartonella henselae strain FDAARGOS_1462 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A829Z6B5 |
| Locus tag | K8O99_RS00985 | Protein ID | WP_034447446.1 |
| Coordinates | 213718..213918 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A0A840E534 |
| Locus tag | K8O99_RS00980 | Protein ID | WP_011180290.1 |
| Coordinates | 213326..213721 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8O99_RS00950 (K8O99_00970) | 208591..209349 | - | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| K8O99_RS00955 (K8O99_00975) | 209409..209924 | - | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| K8O99_RS00960 (K8O99_00980) | 209941..210780 | - | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| K8O99_RS00965 (K8O99_00985) | 210812..211354 | - | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| K8O99_RS00970 (K8O99_00990) | 211951..212529 | - | 579 | WP_011180287.1 | hypothetical protein | - |
| K8O99_RS00975 (K8O99_00995) | 212533..212853 | - | 321 | WP_011180288.1 | hypothetical protein | - |
| K8O99_RS00980 (K8O99_01000) | 213326..213721 | - | 396 | WP_011180290.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K8O99_RS00985 (K8O99_01005) | 213718..213918 | - | 201 | WP_034447446.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K8O99_RS00990 (K8O99_01010) | 213983..214519 | - | 537 | WP_034447444.1 | hypothetical protein | - |
| K8O99_RS00995 (K8O99_01015) | 214530..214976 | - | 447 | WP_011180293.1 | single-stranded DNA-binding protein | - |
| K8O99_RS01000 (K8O99_01020) | 215167..215448 | + | 282 | WP_011180826.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K8O99_RS01005 (K8O99_01025) | 215465..215758 | + | 294 | WP_034447441.1 | HigA family addiction module antitoxin | - |
| K8O99_RS01010 (K8O99_01030) | 215800..216126 | - | 327 | WP_034447437.1 | hypothetical protein | - |
| K8O99_RS01015 (K8O99_01035) | 216291..216710 | - | 420 | WP_038525124.1 | hypothetical protein | - |
| K8O99_RS01020 (K8O99_01040) | 216703..217815 | - | 1113 | WP_011180297.1 | DUF1376 domain-containing protein | - |
| K8O99_RS01025 (K8O99_01045) | 217805..218152 | - | 348 | WP_011180298.1 | DUF1376 domain-containing protein | - |
| K8O99_RS01030 (K8O99_01050) | 218145..218621 | - | 477 | WP_011180299.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 162978..232639 | 69661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7492.81 Da Isoelectric Point: 10.9914
>T215493 WP_034447446.1 NZ_CP082885:c213918-213718 [Bartonella henselae]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFKKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T215493 NZ_CP110790:c134314-133922 [Yersinia massiliensis]
ATGATGTGGATCAGCGCTCAGGAGGTTATCGCTTTTCATGACCGCATATTGCAACGGCTCCCTGGCGTTACTGGTATACC
CGATCCCGGCAGGGCCGAAGCACTCATTTATCGGGTGCAAAACCGAACACATTATGAAGGCGTGACAGATGTTTTTGAAC
TCGGCGCCACCTACTGGGTCGCTATCGCTCGTGGACACATTTTTAACGATGGTAATAAACGTACTGCGTTTTTCGTTACC
ATGGCTTTCCTCTATCGCAATGGCATCAGGATCCGTGATACCGATAATTCGCTGGAAAATTTAACGGTAGCGGCAGCGAC
AGGTGAGAAAACCGTTGACCAGTTAGCGCAACACCTACGAGATTTGGTGGAACATACTAACCAAATTCGTTGA
ATGATGTGGATCAGCGCTCAGGAGGTTATCGCTTTTCATGACCGCATATTGCAACGGCTCCCTGGCGTTACTGGTATACC
CGATCCCGGCAGGGCCGAAGCACTCATTTATCGGGTGCAAAACCGAACACATTATGAAGGCGTGACAGATGTTTTTGAAC
TCGGCGCCACCTACTGGGTCGCTATCGCTCGTGGACACATTTTTAACGATGGTAATAAACGTACTGCGTTTTTCGTTACC
ATGGCTTTCCTCTATCGCAATGGCATCAGGATCCGTGATACCGATAATTCGCTGGAAAATTTAACGGTAGCGGCAGCGAC
AGGTGAGAAAACCGTTGACCAGTTAGCGCAACACCTACGAGATTTGGTGGAACATACTAACCAAATTCGTTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14718.71 Da Isoelectric Point: 4.3191
>AT215493 WP_011180290.1 NZ_CP082885:c213721-213326 [Bartonella henselae]
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSAADEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT215493 NZ_CP110790:c134532-134311 [Yersinia massiliensis]
ATGCGTACTTACACTTCAACCCAAGCTCGAGCAAATATTTCAGAAGTATTGGATGCGGCCACTCATGGCGAACCTGTTGA
AATCACCCGCCGAGACGGTAGCTCAGCAGTAGTTATCAGTAAGGCTGAATTTGAGACATACCAAAACGCTAAGCTGGATG
CAGAGTTCGATGTCATTATGCAACGTCATGGTCATACTGTAGAGGCGCTGACAAACCGATGA
ATGCGTACTTACACTTCAACCCAAGCTCGAGCAAATATTTCAGAAGTATTGGATGCGGCCACTCATGGCGAACCTGTTGA
AATCACCCGCCGAGACGGTAGCTCAGCAGTAGTTATCAGTAAGGCTGAATTTGAGACATACCAAAACGCTAAGCTGGATG
CAGAGTTCGATGTCATTATGCAACGTCATGGTCATACTGTAGAGGCGCTGACAAACCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829Z6B5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A840E534 |