Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
| Location | 207742..208273 | Replicon | chromosome |
| Accession | NZ_CP082885 | ||
| Organism | Bartonella henselae strain FDAARGOS_1462 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | X5M5T9 |
| Locus tag | K8O99_RS00940 | Protein ID | WP_011180281.1 |
| Coordinates | 207992..208273 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A0H3LWD6 |
| Locus tag | K8O99_RS00935 | Protein ID | WP_011180280.1 |
| Coordinates | 207742..208005 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8O99_RS00910 (K8O99_00930) | 203888..204136 | - | 249 | WP_011180274.1 | hypothetical protein | - |
| K8O99_RS00915 (K8O99_00935) | 204140..206068 | - | 1929 | WP_011180275.1 | phage terminase large subunit family protein | - |
| K8O99_RS00920 (K8O99_00940) | 206061..206642 | - | 582 | WP_011180276.1 | hypothetical protein | - |
| K8O99_RS00925 (K8O99_00945) | 206705..207019 | + | 315 | WP_011180277.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K8O99_RS00930 (K8O99_00950) | 207036..207332 | + | 297 | WP_011180278.1 | HigA family addiction module antitoxin | - |
| K8O99_RS00935 (K8O99_00955) | 207742..208005 | + | 264 | WP_011180280.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K8O99_RS00940 (K8O99_00960) | 207992..208273 | + | 282 | WP_011180281.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| K8O99_RS00945 (K8O99_00965) | 208316..208594 | - | 279 | WP_011180242.1 | hypothetical protein | - |
| K8O99_RS00950 (K8O99_00970) | 208591..209349 | - | 759 | WP_011180282.1 | phage antirepressor Ant | - |
| K8O99_RS00955 (K8O99_00975) | 209409..209924 | - | 516 | WP_011180283.1 | phage antirepressor Ant | - |
| K8O99_RS00960 (K8O99_00980) | 209941..210780 | - | 840 | WP_011180284.1 | antA/AntB antirepressor family protein | - |
| K8O99_RS00965 (K8O99_00985) | 210812..211354 | - | 543 | WP_011180285.1 | phage antirepressor Ant | - |
| K8O99_RS00970 (K8O99_00990) | 211951..212529 | - | 579 | WP_011180287.1 | hypothetical protein | - |
| K8O99_RS00975 (K8O99_00995) | 212533..212853 | - | 321 | WP_011180288.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 162978..232639 | 69661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11106.85 Da Isoelectric Point: 10.3380
>T215492 WP_011180281.1 NZ_CP082885:207992-208273 [Bartonella henselae]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL
Download Length: 282 bp
>T215492 NZ_CP110790:109527-109898 [Yersinia massiliensis]
ATGAAACCACGACCCACCCCACAGGGCGCATTGCCCGTGCCTGTTATTTATCAGCAACTACTTGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACGGGAGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GATCCCATGCTGAGCAAGGGTGATATTGCACGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCACAGAGACCGTTAACATGA
ATGAAACCACGACCCACCCCACAGGGCGCATTGCCCGTGCCTGTTATTTATCAGCAACTACTTGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACGGGAGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GATCCCATGCTGAGCAAGGGTGATATTGCACGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCACAGAGACCGTTAACATGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9565.81 Da Isoelectric Point: 4.1403
>AT215492 WP_011180280.1 NZ_CP082885:207742-208005 [Bartonella henselae]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD
Download Length: 264 bp
>AT215492 NZ_CP110790:109895-110227 [Yersinia massiliensis]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGCAATGTGATATTACGCCGCGGTTGGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGGGCGCTGGATCCACGCCGCCAGCAAGGC
ATTACGGTTCGGCATGGAGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCTGTGTATCA
GAAACTGGCTTGA
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGCAATGTGATATTACGCCGCGGTTGGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGGGCGCTGGATCCACGCCGCCAGCAAGGC
ATTACGGTTCGGCATGGAGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCTGTGTATCA
GAAACTGGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R4J6H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3LWD6 |