Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1052350..1054094 Replicon chromosome
Accession NZ_CP082883
Organism Burkholderia dolosa strain FDAARGOS_1463

Toxin (Protein)


Gene name doc Uniprot ID A0A892IG78
Locus tag K8O94_RS20755 Protein ID WP_006766124.1
Coordinates 1052350..1053240 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A892IEP8
Locus tag K8O94_RS20760 Protein ID WP_006766123.1
Coordinates 1053237..1054094 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O94_RS20725 (K8O94_20660) 1047727..1048806 - 1080 WP_035974291.1 porin -
K8O94_RS20730 (K8O94_20665) 1049251..1049568 + 318 WP_006766129.1 non-heme iron oxygenase ferredoxin subunit -
K8O94_RS20735 (K8O94_20670) 1049570..1049881 + 312 WP_006766128.1 hypothetical protein -
K8O94_RS20740 (K8O94_20675) 1049943..1051013 + 1071 WP_006766127.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
K8O94_RS20745 (K8O94_20680) 1051006..1051776 + 771 WP_035975317.1 SDR family oxidoreductase -
K8O94_RS20750 (K8O94_20685) 1051804..1052331 + 528 WP_035975316.1 cupin domain-containing protein -
K8O94_RS20755 (K8O94_20690) 1052350..1053240 + 891 WP_006766124.1 alpha/beta fold hydrolase Toxin
K8O94_RS20760 (K8O94_20695) 1053237..1054094 + 858 WP_006766123.1 IclR family transcriptional regulator Antitoxin
K8O94_RS20765 (K8O94_20700) 1054174..1054971 + 798 WP_035974289.1 SDR family oxidoreductase -
K8O94_RS20770 (K8O94_20705) 1054964..1056631 + 1668 WP_035974287.1 thiamine pyrophosphate-binding protein -
K8O94_RS20775 (K8O94_20710) 1056624..1057451 + 828 WP_006766122.1 aspartate dehydrogenase -
K8O94_RS20780 (K8O94_20715) 1057543..1059033 + 1491 WP_035974286.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-276)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30188.38 Da        Isoelectric Point: 6.6302

>T215490 WP_006766124.1 NZ_CP082883:1052350-1053240 [Burkholderia dolosa]
MTVIEKRERAAAFAALLEQFPEQRCAAGAAGTIGYREAGAQQADRALPVVLLHGIGSGAASWVRQLDALGAVRRVLAWDA
PGYGASTPVRAASPVAADYAAALDAWLDALGIERCVVVGHSLGAIVAGGMVSAMPARIAGLLLISPAGGYGSASADTRNA
RRDARLAMLAALGPAGLAEQRSGNMLSGFASDDARAWVRWNMARIVPDGYAQATHLLANADLAADVAGFAGHAAVAVGAN
DAITPPAACERIAAALGVELQVVPQAGHAGYVEAPAIYSALIDAFCRSCDTQRRPA

Download         Length: 891 bp

>T215490 NZ_CP110789:3574973-3575176 [Yersinia intermedia]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTAGAACGTGTAATTGAAAAGAATAA
GTATGAGCTTTCCGATGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCATCGTCTGGCTGAACTCACAATGAATAAGC
TTTACGATAAAATTCCTCCTACGGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31426.97 Da        Isoelectric Point: 8.0592

>AT215490 WP_006766123.1 NZ_CP082883:1053237-1054094 [Burkholderia dolosa]
MSAPLQRQAADDAKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYR
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQELYALYPERTLNRMTSATPETVDALYEAIREDARRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 858 bp

>AT215490 NZ_CP110789:3574557-3574925 [Yersinia intermedia]
ATGGATGAGTACTCGCCTAAACGGCATGACATTGCCCAGTTGAAGTTTCTATGTGAGAGCCTGTATGATGAAGGCATTGC
TACCCTTGGTGACAGCCATCATGGCTGGGTAAATGACCCAACATCTGCCGTAAATCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCTGAATTGAGGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTAAGACTTTTCTCAGGGGAATACACCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References