Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 809357..810607 Replicon chromosome
Accession NZ_CP082883
Organism Burkholderia dolosa strain FDAARGOS_1463

Toxin (Protein)


Gene name vapC Uniprot ID A0A892IA44
Locus tag K8O94_RS19650 Protein ID WP_006766297.1
Coordinates 809357..809956 (-) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A892I3E7
Locus tag K8O94_RS19655 Protein ID WP_035974448.1
Coordinates 810050..810607 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O94_RS19625 (K8O94_19565) 804379..805176 + 798 WP_035974452.1 enoyl-CoA hydratase -
K8O94_RS19630 (K8O94_19570) 805173..806312 + 1140 WP_006766300.1 enoyl-CoA hydratase/isomerase family protein -
K8O94_RS19635 (K8O94_19575) 806399..807304 - 906 WP_035974451.1 LysR family transcriptional regulator -
K8O94_RS19640 (K8O94_19580) 807477..809015 + 1539 WP_006766298.1 MFS transporter -
K8O94_RS19645 809119..809360 - 242 Protein_721 SAM-dependent methyltransferase -
K8O94_RS19650 (K8O94_19585) 809357..809956 - 600 WP_006766297.1 HD domain-containing protein Toxin
K8O94_RS19655 (K8O94_19590) 810050..810607 - 558 WP_035974448.1 helix-turn-helix transcriptional regulator Antitoxin
K8O94_RS19660 (K8O94_19595) 810952..812355 + 1404 WP_006766295.1 hypothetical protein -
K8O94_RS19665 (K8O94_19600) 812471..813729 + 1259 Protein_725 IS256 family transposase -
K8O94_RS19670 (K8O94_19605) 813770..813949 + 180 Protein_726 integrase core domain-containing protein -
K8O94_RS19675 814010..814439 - 430 Protein_727 transposase -
K8O94_RS19680 (K8O94_19615) 814730..815227 + 498 WP_123806756.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-49)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 21892.64 Da        Isoelectric Point: 5.1098

>T215489 WP_006766297.1 NZ_CP082883:c809956-809357 [Burkholderia dolosa]
MTPDTIHARLDFLREAERLKDVLRSGRTSSGRAESTAEHSWRLCLMALAFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERNDLLTLTAALDGPLRDEIVALWDEYEAVATPEARAAKALDKLETILQHNQGDNPPDFDYAFNLDY
GRRYTDAAPLFIAIRAVVDADTQRRIDARAHTACTKGSA

Download         Length: 600 bp

>T215489 NZ_CP110789:c2234733-2234275 [Yersinia intermedia]
ATGATGTTCTATCGCATCGTGATGCGCCGCTACCTTGCTTCAACCTGGACCGGTTATGGCGCTGAAATCTATGGTGGGCG
TTGGAATCATAAAGGCCACGCCGCCATCTATTTAGCCAGTAGTGTGTCACTGGCTATGCTGGAAACACTGGTACATATTC
AAGACAGCTCAACACTCAGCGAGTTTGAGTTATTCCAGATTGAGATTGATGACAGCAATATCATGCTGTTACAACCACAG
GATTGGCCACTGGACTGGCGCAATGATCCCGCGCCTGCGGCTACGATGGATATCGGCACAGAATGGCTGGAATCAGAATC
ATCAATTGGATTGCTGGTCCCATCCACACTGGTGCCTTCAGAACATAATATGCTGGTCAATCCGCGCCACAAAGATTTTC
AGGCCTGCTTGAGTACCGCCAAAGCACTCGCCTTTGCTTTCGATCCCCGATTGAAATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20283.30 Da        Isoelectric Point: 8.8096

>AT215489 WP_035974448.1 NZ_CP082883:c810607-810050 [Burkholderia dolosa]
MAAPALHTPPLGPQLKRWRVLHRIKQSHAAELFGVAQSTISRWEAGIQQMSADERATAERLLAAHLDSAGDHALARLIAD
SAGRMHLVCDLTHRLLACSPLRAAEFSQPLPLLLGTSLWRYATPEIVRMESALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETL

Download         Length: 558 bp

>AT215489 NZ_CP110789:c2235265-2234819 [Yersinia intermedia]
ATGAGAGCTTATCAACCTACCCCCACAACGAAAGCAGGGGCACTCTGGCGGGAAATTGGTTTGCCAGCCAGCCGTGGCAC
GGTATTAGTCGACAGCATCAAGCTGGGTTTTTCTGTCGATGTCATCGACAGTATCCATCTTTGGGCCTCTATGCCTAAAT
CTGAAATATTGCGCGCTACCGGTATTCCCAGCCGTAGCCTGACCCGCCGACGCACCCATGATGGCCGTTTTACACCAGAA
GAGAGTGAGCGAATCGCGCGCTTCGTGCGGGTAATGGATGCCGCAGTTGACCTCTTCGGTGGTGATAAAGGCAAAGCTAT
CGTCTGGATGTCGACGCCCATTAAGGGGCTTGGGCACCGCAGCCCTGACTCACTGCTGGAGACCGAAACCGGTGCGTTAG
AAATCTGCGATTTAATTGGGCGGCTGGAACACGGTGTATTTTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References