Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2082162..2083765 Replicon chromosome
Accession NZ_CP082863
Organism Cupriavidus pauculus strain FDAARGOS_1472

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K8O84_RS27160 Protein ID WP_170292625.1
Coordinates 2082440..2083765 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K8O84_RS27155 Protein ID WP_150981886.1
Coordinates 2082162..2082440 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O84_RS27130 (K8O84_27030) 2077980..2078468 + 489 WP_150981883.1 hypothetical protein -
K8O84_RS27135 (K8O84_27035) 2078465..2079196 + 732 WP_150981884.1 3-oxoacyl-ACP reductase FabG -
K8O84_RS27140 (K8O84_27040) 2079193..2080428 + 1236 WP_150981885.1 beta-ketoacyl-ACP synthase -
K8O84_RS27145 (K8O84_27045) 2080479..2081144 + 666 WP_223506097.1 4'-phosphopantetheinyl transferase superfamily protein -
K8O84_RS27150 (K8O84_27050) 2081179..2081913 - 735 WP_061955821.1 IclR family transcriptional regulator -
K8O84_RS27155 (K8O84_27055) 2082162..2082440 + 279 WP_150981886.1 helix-turn-helix transcriptional regulator Antitoxin
K8O84_RS27160 (K8O84_27060) 2082440..2083765 + 1326 WP_170292625.1 type II toxin-antitoxin system HipA family toxin Toxin
K8O84_RS27165 (K8O84_27065) 2084130..2084438 + 309 WP_150981888.1 hydroxyquinol 1,2-dioxygenase -
K8O84_RS27170 (K8O84_27070) 2084515..2085315 + 801 WP_223506098.1 alpha/beta hydrolase -
K8O84_RS27175 (K8O84_27075) 2086082..2087404 + 1323 WP_150981889.1 oxalate/formate MFS antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 48469.42 Da        Isoelectric Point: 8.7805

>T215484 WP_170292625.1 NZ_CP082863:2082440-2083765 [Cupriavidus pauculus]
MGRRAQRRRLGVWMNGWRAGVWEQGADGEAFAYDEDWMASPQGRPLSLSLPFRADNAPYRGSIVTDYFDNLLPDSDAIRR
RLALRHRTQGTGPFDLLAALGRDCVGALQLLPDDTVPEGLHRIEGTVVGEAAIARLLRDTTRNTAVLGQPDDSGDLRLSI
AGAQEKTALLYRNGKWLLPHGSTPTTHILKLPLGLVGNMRADMRTSVENEWLCAQLVGHFGLPIARCDIARFEDQKVLVV
ERFDRRLAPDGKWIVRLPQEDFCQALGISPLSKYQADGGPGIGDIMAVLAGSEAPAHDRRNFFATQVLFWMLAATDGHAK
NFSLSIGPGGRYWSTPLYDVLSAFPIMGRGASQLAPQKARMAMAVRGSQNHYRIAEIMRRHWLDQGRQAGLPAEEVETVL
AALKGAVEHAIAMATAQLPADFPADVADRVFKGLRAQARKL

Download         Length: 1326 bp

>T215484 NZ_CP110789:c390841-389513 [Yersinia intermedia]
ATGACTCGCCGCATTAAACGGCTCAATATCTGGATGAACGGTCAGTATGTTGGCTATTGGGAAAAAACCCGAGGCGAAGA
ATCACTGGTTTATGCTCAAGAATGGATAGAGAACGCGCAAGGCCGCCCACTGTCATTGTCATTACCTTTTACTGCAAATA
ATCAGGTTTATAGAGGCAATATTGTCCGGGACTATTTTGATAACTTATTACCCGATAGCGATGATATCCGGCGGCGTCTG
GCAACCAGATATCACGCTGACAGCATCAACCCTTTCGATCTACTCTTTGAATTAGGGAGAGATTGTGTCGGCGCAATACA
ATTGCTGGCAAATGATACCCCCCCTGCCGATCTATTCTCAATTCAACAACAGCCACTAACTGAGCACGATGTGGCTCGTA
TCCTACGAAACTCATGGTCTGACAATACATTTGTGCGCCCTGAACACAATGAAGATCTCAGATTATCTATCGCGGGGGCA
CAAGAAAAAACAGCGCTGTTGTTTCACGATGACCGGTGGTGTCTCCCGTTGGGCAGCACTCCAACAACCCATATTTTCAA
ACTTCCTTTGGGCTTGGTCGGCAATATGCAAGCTGATATGAGGACTTCTGTTGAAAACGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTGCCAGTTGCCCGTAGTGAAATTGGCCAGTTTGAAGATCAAAAAGCACTGATTGTTGAGCGTTTT
GACCGGCGGTTATCACGTGACAATCGTTGGATTGTCAGATTACCGCAGGAAGATATGTGTCAGGCCTCCGGGACTTCACC
CTTGAAAAAATACCAAATAGATGGCGGCCCTAGTATGACAACTATCATGGGGATTTTAAGTGGTTCGGATAATGCCAGTG
AAGACAGAAACCTCTTCTTTAAAACACAGATTATTTTCTGGTTACTGGCAGCAACCGATGGGCATGCAAAAAATTTCAGC
ATTGCTCATCTACCCAGAAATAGTTACCACCTCACGCCACTTTATGATGTGCTATCGACCCATCCGATTATCGGCTCAAG
TCATAATCAAATTGCGATACAAAAAGCCAAGTTAGCGATGGCCGTTCGAGGGAGTAAAAATTACTATTTAATTAACCAGA
TACAGCGGCGCCATTGGCGAAAACAGGCCGAGCTTGTTGGGCTAGGAGCGTATCTTGCTGATAGTATTATTGATGAAGTT
ATTACCGCAACCCCGAGGGTAATAGCACAAATACAAGCCCAGCTTCCCGCTAATTTTCCAACTGATTTAGCAGAAAGTAT
CCTCACAGGTCTTCATCGACAGTGTGATAAAATAGCGGCAATGTCTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9937.56 Da        Isoelectric Point: 11.7593

>AT215484 WP_150981886.1 NZ_CP082863:2082162-2082440 [Cupriavidus pauculus]
MAATYPIRILSQLRPVLQGLRKSRGLTQAALAARLGVSQQSYARLEANPGRASMARVLAALQALEVDLALTPRGDTSATA
PRPKKAKQKEDW

Download         Length: 279 bp

>AT215484 NZ_CP110789:c391142-390843 [Yersinia intermedia]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCAACCTTGATTGGCTTTCGTAAGCAGAAAGGGCTAACTCAGGC
CAGCCTGGCACAACTGTTAGGTATCACCCAGCAATCCTATGCAAAATTGGAGGCAGATCCTGCATCGGCCAGTATTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTCATCCTCTGTGAGAAAAAAAACGTCAGGTTGTATTCAAGTAAA
ACCCACCAGCCAGAAGAAAGTCAGACGCTAAATTTGCCGTCAAAACAAGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References