Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1669251..1670716 Replicon chromosome
Accession NZ_CP082862
Organism Cupriavidus pauculus strain FDAARGOS_1472

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag K8O84_RS07970 Protein ID WP_150982220.1
Coordinates 1669853..1670716 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag K8O84_RS07965 Protein ID WP_062794306.1
Coordinates 1669251..1669856 (+) Length 202 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O84_RS07940 (K8O84_07905) 1664458..1665858 - 1401 WP_211922785.1 DUF1214 domain-containing protein -
K8O84_RS07945 (K8O84_07910) 1666415..1666876 - 462 WP_150982218.1 hypothetical protein -
K8O84_RS07950 (K8O84_07915) 1666897..1667145 - 249 WP_020200504.1 hypothetical protein -
K8O84_RS07955 (K8O84_07920) 1667162..1668370 - 1209 WP_150982219.1 XRE family transcriptional regulator -
K8O84_RS07960 (K8O84_07925) 1668367..1669023 - 657 WP_046432185.1 hypothetical protein -
K8O84_RS07965 (K8O84_07930) 1669251..1669856 + 606 WP_062794306.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
K8O84_RS07970 (K8O84_07935) 1669853..1670716 + 864 WP_150982220.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
K8O84_RS07975 (K8O84_07940) 1670799..1671131 + 333 WP_211922786.1 hypothetical protein -
K8O84_RS07980 (K8O84_07945) 1671243..1671524 - 282 WP_249043172.1 DUF2220 family protein -
K8O84_RS07985 (K8O84_07950) 1671603..1671875 + 273 WP_201764134.1 hypothetical protein -
K8O84_RS07990 (K8O84_07955) 1672347..1672559 + 213 WP_150982227.1 helix-turn-helix domain-containing protein -
K8O84_RS07995 (K8O84_07960) 1672657..1673229 + 573 WP_150982221.1 Hsp20/alpha crystallin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1666415..1686465 20050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-55)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 31303.24 Da        Isoelectric Point: 5.7432

>T215483 WP_150982220.1 NZ_CP082862:1669853-1670716 [Cupriavidus pauculus]
MSAATPNVAASVRARLLNVAKAQGVDFNQVLVRFALERILYRLTQSPHADRFLLKGALLFTLWYDMPHRATRDADLLGFG
ASDLESVAQVFRDIAAVPVDDGIVFDPASVTVEEIRKEAGYGGVRVMIAGDLARARCKTQIDVGFGDAVTPAPVDSVYPV
LLEEMPAPRLRAYPTYTVIAEKLHAIALLGMTNSRLKDYFDLSVLLERETLDTDLLAQAIKATFERRGMAVPDALPVGLT
DEFAHDASRQALWLAFLKKNELPPEPLPAIVGRLSVALAPALNVVAR

Download         Length: 864 bp

>T215483 NZ_CP110789:53108-53527 [Yersinia intermedia]
ATGATGAAAAGAATATATATGCTCGATACGAATATTTGCTCTTTTATTATGCGGGAACGCCCTGCTGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTCGTTTCAGCCATTACATACTCAGAAATGCGGTTTGGTGCAATTG
GTAAGAAAGCATCACCGAAACATAACTATTTAGTAGATGAATTTGTGAAACGATTAGATGCTATCTTGTCGTGGGATGCA
GCGGCTGTAGATGCTACCACTAATATTAAAGTTGAGCTGGCAAAGCAGGGTACGCCAATTGGCGGAAATGATGCAGCAAT
AGCCGGACACGCAATTTCGGCTGGAGCAATATTAGTGACTAATAACATTAGAGAGTTTGAAAGAGTTAAAAAGCTGCGAA
TTGAGGATTGGAGTAAATAA

Antitoxin


Download         Length: 202 a.a.        Molecular weight: 22241.81 Da        Isoelectric Point: 9.9042

>AT215483 WP_062794306.1 NZ_CP082862:1669251-1669856 [Cupriavidus pauculus]
MLSSTHNQRVLDLASQKGLLRASDLDAISAPRVVLTRLTAAGLLEKVGRGLYRLPDAQVSEFESLGTIATKVPQAVFCLL
TALQFHELTTQLPRQIWIAMPRGSHPPRVDYPPVKMVQFTGDAYSAGIEEVERDGVRLRVYGVAKTVADCFKHRNKIGLD
VALEALKDARARSKASVDDIWRFAKICRVANVMRPYLESVG

Download         Length: 606 bp

>AT215483 NZ_CP110789:52884-53111 [Yersinia intermedia]
ATGAGAACAGTTTCTATTTTCAAAAATGGCCAAAATCGGGCAATACGTTTACCAAAAGATATGGACTTTGCGGGTGTCAC
TGAACTGGAAATACTCAAAGATGGCGATAATATCATTTTAAGACCTATCCGCCCTACATGGGTATCATTCATGGATGAAG
ATAAAGCGGATAACGATTTTCTTGCGGAAAGACAAGACGTTATCGAAGAGGGACGCTTCGAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References