Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4269952..4270423 Replicon chromosome
Accession NZ_CP082860
Organism Enterobacter ludwigii strain FDAARGOS_1475

Toxin (Protein)


Gene name relE Uniprot ID A0A839BQT8
Locus tag K8P07_RS20455 Protein ID WP_020885403.1
Coordinates 4269952..4270191 (-) Length 80 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A839BTQ9
Locus tag K8P07_RS20460 Protein ID WP_020885404.1
Coordinates 4270181..4270423 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P07_RS20440 (K8P07_20360) 4266222..4266794 + 573 WP_149376281.1 PTS sugar transporter subunit IIA -
K8P07_RS20445 (K8P07_20365) 4267162..4269300 + 2139 WP_020885401.1 anaerobic ribonucleoside-triphosphate reductase -
K8P07_RS20450 (K8P07_20370) 4269439..4269903 + 465 WP_020885402.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K8P07_RS20455 (K8P07_20375) 4269952..4270191 - 240 WP_020885403.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8P07_RS20460 (K8P07_20380) 4270181..4270423 - 243 WP_020885404.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8P07_RS20465 (K8P07_20385) 4270501..4272411 - 1911 WP_020885405.1 PRD domain-containing protein -
K8P07_RS20470 (K8P07_20390) 4272431..4273567 - 1137 WP_020885406.1 lactonase family protein -
K8P07_RS20475 (K8P07_20395) 4273686..4274426 - 741 WP_020882900.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-77)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9093.63 Da        Isoelectric Point: 9.9348

>T215482 WP_020885403.1 NZ_CP082860:c4270191-4269952 [Enterobacter ludwigii]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPRVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIG

Download         Length: 240 bp

>T215482 NZ_CP110785:c8457-8119 [Staphylococcus capitis]
ATGAGTATCAAACAGTTTGATATATACTATATTGACCTAGACCCCACTCGAGGTCGTGAAAAACAAAAAATCAGACCGTG
CTTAATCGTAAATAATAAAATGACAATAGATGGTACAAATTTCGTTTGGGTATTACCAATCACAAATCGCGAGAAACGTT
ATCCATTGGATATTGAACTCAAAACTAAAAAAGGTTTAGTCACAGGCGTTATAGACACGTTACAGATACGTGCATTAGAC
CTTAGTGTACGCGAACATAACTATAAAGATAAATTACAAGACAACTTAAAAAACGTCGTCTTACAAGCAATACAAACGTA
TCTAAAACCATCATCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9085.49 Da        Isoelectric Point: 5.1088

>AT215482 WP_020885404.1 NZ_CP082860:c4270423-4270181 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Download         Length: 243 bp

>AT215482 NZ_CP110785:c8702-8454 [Staphylococcus capitis]
ATGATTAAAACATCTGAACGCATATTCAAAAGTGGAAACAGTAGAGCAATCAGTTTAAGCAAACAAACAATCCAACTTGC
TGATTTTGAAGTAGGAGATAAGGTTGAAGTATCTGAAATCAATGGTGGTTTGTTTATCAAAAAGAAAGAAGAATCGATTG
AAGATGAAATCACAAATTTTTTCAAAAATGGTGGTAGATACACCGAGTCAGAAATTGATTTTGGAGAAAGTGTAGGTCGT
GAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BQT8

Antitoxin

Source ID Structure
AlphaFold DB A0A839BTQ9

References