Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3713009..3713629 Replicon chromosome
Accession NZ_CP082860
Organism Enterobacter ludwigii strain FDAARGOS_1475

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag K8P07_RS17820 Protein ID WP_014168902.1
Coordinates 3713411..3713629 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag K8P07_RS17815 Protein ID WP_020885187.1
Coordinates 3713009..3713383 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P07_RS17805 (K8P07_17745) 3708135..3709328 + 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K8P07_RS17810 (K8P07_17750) 3709351..3712497 + 3147 WP_223398366.1 multidrug efflux RND transporter permease subunit AcrB -
K8P07_RS17815 (K8P07_17755) 3713009..3713383 + 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
K8P07_RS17820 (K8P07_17760) 3713411..3713629 + 219 WP_014168902.1 HHA domain-containing protein Toxin
K8P07_RS17825 (K8P07_17765) 3713839..3714390 + 552 WP_020885188.1 maltose O-acetyltransferase -
K8P07_RS17830 (K8P07_17770) 3714508..3714975 + 468 WP_020885189.1 YlaC family protein -
K8P07_RS17835 (K8P07_17775) 3714947..3716407 - 1461 WP_223398367.1 PLP-dependent aminotransferase family protein -
K8P07_RS17840 (K8P07_17780) 3716508..3717218 + 711 WP_020885191.1 GNAT family protein -
K8P07_RS17845 (K8P07_17785) 3717215..3717355 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
K8P07_RS17850 (K8P07_17790) 3717358..3717618 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T215481 WP_014168902.1 NZ_CP082860:3713411-3713629 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T215481 NZ_CP110784:c2141521-2141255 [Staphylococcus capitis]
ATGGCTAAATATAAAATCAACATAAAGAATTCAGCGAAGACAGATTTGAATAAGATAAAACGTTCTCACTTACAAGAACA
ATTTTTGAAAATCGTAGAAATATTAAAATATGATCCATATCAACAAAGTCAATCCTTTGAAAAATTGCACCCTAAACATT
TAGGACGATACTCAAGACGTATCAATCATCAACATAGAGTTGTCTATACAATTGATGAGGAAAATAAAGAAGTATTAATA
TTAGCAGCTTGGTCTCATTATGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT215481 WP_020885187.1 NZ_CP082860:3713009-3713383 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT215481 NZ_CP110784:c2141778-2141521 [Staphylococcus capitis]
ATGAAAAGTAAAACACCAACAGAAGCTCGTAAAGATTTTTATCAGTTATTAAAACGTGTGAATAATGACCATGAACCAGT
ATATATTGAAGGCAAATATGATGAGAGTAATGCTGTTATTATAGGCATGGAAGATTGGCGTAGCATTAATGAAACGATAT
ATCTTGAGGCTACAGGCACAATGGACAAAGTTAGAGAACGTGAGCATGACAACAGTGGTTATACAAACATAGATGATATT
GATTGGGCTAGACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References