Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 891283..891940 Replicon chromosome
Accession NZ_CP082860
Organism Enterobacter ludwigii strain FDAARGOS_1475

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag K8P07_RS04370 Protein ID WP_014171514.1
Coordinates 891530..891940 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag K8P07_RS04365 Protein ID WP_003863437.1
Coordinates 891283..891549 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P07_RS04345 (K8P07_04335) 886690..888123 - 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -
K8P07_RS04350 (K8P07_04340) 888240..888971 - 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
K8P07_RS04355 (K8P07_04345) 889238..889897 + 660 WP_014171517.1 hemolysin III family protein -
K8P07_RS04360 (K8P07_04350) 890008..890988 - 981 WP_047356717.1 tRNA-modifying protein YgfZ -
K8P07_RS04365 (K8P07_04355) 891283..891549 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
K8P07_RS04370 (K8P07_04360) 891530..891940 + 411 WP_014171514.1 protein YgfX Toxin
K8P07_RS04375 (K8P07_04365) 891947..892468 - 522 WP_014171513.1 flavodoxin FldB -
K8P07_RS04380 (K8P07_04370) 892570..893466 + 897 WP_223398772.1 site-specific tyrosine recombinase XerD -
K8P07_RS04385 (K8P07_04375) 893490..894203 + 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8P07_RS04390 (K8P07_04380) 894209..895942 + 1734 WP_223398773.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T215472 WP_014171514.1 NZ_CP082860:891530-891940 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T215472 NZ_CP110782:260206-260502 [Pseudomonas putida DOT-T1E]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGTCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
TGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT215472 WP_003863437.1 NZ_CP082860:891283-891549 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT215472 NZ_CP110782:259916-260161 [Pseudomonas putida DOT-T1E]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References