Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4819529..4820183 Replicon chromosome
Accession NZ_CP082859
Organism Gordonia bronchialis strain FDAARGOS_1476

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8O93_RS22955 Protein ID WP_052298363.1
Coordinates 4819529..4819948 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8O93_RS22960 Protein ID WP_083775533.1
Coordinates 4819938..4820183 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O93_RS22945 (K8O93_22745) 4817886..4818320 - 435 WP_012833025.1 MarR family transcriptional regulator -
K8O93_RS22950 (K8O93_22750) 4818418..4819518 + 1101 WP_012833026.1 epoxide hydrolase -
K8O93_RS22955 (K8O93_22755) 4819529..4819948 - 420 WP_052298363.1 PIN domain-containing protein Toxin
K8O93_RS22960 (K8O93_22760) 4819938..4820183 - 246 WP_083775533.1 hypothetical protein Antitoxin
K8O93_RS22965 (K8O93_22765) 4820218..4821098 - 881 Protein_4544 ATP-binding protein -
K8O93_RS22970 (K8O93_22770) 4821223..4821510 - 288 WP_012833029.1 hypothetical protein -
K8O93_RS22975 (K8O93_22775) 4821672..4821860 - 189 Protein_4546 glyoxalase -
K8O93_RS22980 (K8O93_22780) 4821904..4822332 + 429 WP_223373429.1 hypothetical protein -
K8O93_RS22985 (K8O93_22785) 4822515..4823630 + 1116 WP_012833038.1 DNA polymerase IV -
K8O93_RS22990 (K8O93_22790) 4823690..4824600 + 911 Protein_4549 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15188.41 Da        Isoelectric Point: 6.2135

>T215471 WP_052298363.1 NZ_CP082859:c4819948-4819529 [Gordonia bronchialis]
MLLDINVLVALSWDQHVHHGVAHERFAQLTEWSTCPVTEAGLVRVLMTESAVGRVVTGAEALGQLAALRTVTGWGFLHDD
ASLADSVIDLRVLMGRRQVTDLHLVNLAARNGRKLATFDAGLRESLVPADRAWVEVWSA

Download         Length: 420 bp

>T215471 NZ_CP110782:259916-260161 [Pseudomonas putida DOT-T1E]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8087.99 Da        Isoelectric Point: 4.6140

>AT215471 WP_083775533.1 NZ_CP082859:c4820183-4819938 [Gordonia bronchialis]
VRTTLDLDPVVLSAARAKAKADGISLGKAVSELARAGLSAPRSAAATSAPSGFPVLTGVPGHPVTDDAVAEYRDDDVTDA
S

Download         Length: 246 bp

>AT215471 NZ_CP110782:260206-260502 [Pseudomonas putida DOT-T1E]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGTCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
TGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References