Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1835282..1835913 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag K8O83_RS09460 Protein ID WP_005651560.1
Coordinates 1835515..1835913 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag K8O83_RS09455 Protein ID WP_005648011.1
Coordinates 1835282..1835515 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O83_RS09430 (K8O83_09320) 1830761..1831963 - 1203 WP_006995609.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
K8O83_RS09435 (K8O83_09325) 1832127..1832792 + 666 WP_013527272.1 DNA repair protein RadC -
K8O83_RS09440 (K8O83_09330) 1833006..1833242 + 237 WP_006995608.1 50S ribosomal protein L28 -
K8O83_RS09445 (K8O83_09335) 1833254..1833424 + 171 WP_005613503.1 50S ribosomal protein L33 -
K8O83_RS09450 (K8O83_09340) 1833771..1835135 + 1365 WP_006995606.1 diaminobutyrate--2-oxoglutarate transaminase -
K8O83_RS09455 (K8O83_09345) 1835282..1835515 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K8O83_RS09460 (K8O83_09350) 1835515..1835913 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
K8O83_RS09465 (K8O83_09355) 1835933..1837468 + 1536 WP_006995605.1 L-2,4-diaminobutyrate decarboxylase -
K8O83_RS09470 (K8O83_09360) 1837711..1838526 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
K8O83_RS09475 (K8O83_09365) 1838600..1839622 - 1023 WP_065246977.1 outer membrane-stress sensor serine endopeptidase DegS -
K8O83_RS09480 (K8O83_09370) 1839623..1840741 - 1119 WP_006995603.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T215470 WP_005651560.1 NZ_CP082857:1835515-1835913 [Haemophilus aegyptius]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T215470 NZ_CP110778:c32589-32173 [Citrobacter freundii]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT215470 WP_005648011.1 NZ_CP082857:1835282-1835515 [Haemophilus aegyptius]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT215470 NZ_CP110778:c32816-32586 [Citrobacter freundii]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References