Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1252954..1253607 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8O83_RS06770 Protein ID WP_006996056.1
Coordinates 1253215..1253607 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag K8O83_RS06765 Protein ID WP_006996057.1
Coordinates 1252954..1253214 (+) Length 87 a.a.

Genomic Context

K8O83_RS06760K8O83_RS06765K8O83_RS06770K8O83_RS06775K8O83_RS06780K8O83_RS06785K8O83_RS06750K8O83_RS06755
Location: 1251396..1252871 (1476 bp)
Type: Others
Protein ID: WP_006996058.1
Location: 1252954..1253214 (261 bp)
Type: Antitoxin
Protein ID: WP_006996057.1
Location: 1253215..1253607 (393 bp)
Type: Toxin
Protein ID: WP_006996056.1
Location: 1254165..1255481 (1317 bp)
Type: Others
Protein ID: WP_223395539.1
Location: 1255647..1257314 (1668 bp)
Type: Others
Protein ID: WP_006996054.1
Location: 1257393..1257824 (432 bp)
Type: Others
Protein ID: WP_167395599.1
Location: 1248805..1249770 (966 bp)
Type: Others
Protein ID: WP_006996060.1
Location: 1249767..1251281 (1515 bp)
Type: Others
Protein ID: WP_006996059.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8O83_RS06750 (K8O83_06675)1248805..1249770-966WP_006996060.1tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB-
K8O83_RS06755 (K8O83_06680)1249767..1251281-1515WP_006996059.1sodium/proline symporter PutP-
K8O83_RS06760 (K8O83_06685)1251396..1252871+1476WP_006996058.1ribonuclease G-
K8O83_RS06765 (K8O83_06690)1252954..1253214+261WP_006996057.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
K8O83_RS06770 (K8O83_06695)1253215..1253607+393WP_006996056.1type II toxin-antitoxin system VapC family toxinToxin
K8O83_RS06775 (K8O83_06700)1254165..1255481+1317WP_223395539.1YadA-like family protein-
K8O83_RS06780 (K8O83_06705)1255647..1257314+1668WP_006996054.1glutamine--tRNA ligase-
K8O83_RS06785 (K8O83_06710)1257393..1257824+432WP_167395599.1YcgN family cysteine cluster protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14758.20 Da        Isoelectric Point: 4.6908

>T215467 WP_006996056.1 NZ_CP082857:1253215-1253607 [Haemophilus aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFEFVPNLILENWCSV

Download         Length: 393 bp

>T215467 NZ_CP110775:c4595552-4595334 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT215467 WP_006996057.1 NZ_CP082857:1252954-1253214 [Haemophilus aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp

>AT215467 NZ_CP110775:c4595954-4595580 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5C2R5S0

References