Detailed information of TA system TA215467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1252954..1253607
• Replicon: chromosome
• Accession: NZ_CP082857
• Organism: Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K8O83_RS06770
• Protein ID: WP_006996056.1
• Coordinates: 1253215..1253607 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C2R5S0
• Locus tag: K8O83_RS06765
• Protein ID: WP_006996057.1
• Coordinates: 1252954..1253214 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O83_RS06750 (K8O83_06675)	1248805..1249770	-	966	WP_006996060.1	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	-
K8O83_RS06755 (K8O83_06680)	1249767..1251281	-	1515	WP_006996059.1	sodium/proline symporter PutP	-
K8O83_RS06760 (K8O83_06685)	1251396..1252871	+	1476	WP_006996058.1	ribonuclease G	-
K8O83_RS06765 (K8O83_06690)	1252954..1253214	+	261	WP_006996057.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
K8O83_RS06770 (K8O83_06695)	1253215..1253607	+	393	WP_006996056.1	type II toxin-antitoxin system VapC family toxin	Toxin
K8O83_RS06775 (K8O83_06700)	1254165..1255481	+	1317	WP_223395539.1	YadA-like family protein	-
K8O83_RS06780 (K8O83_06705)	1255647..1257314	+	1668	WP_006996054.1	glutamine--tRNA ligase	-
K8O83_RS06785 (K8O83_06710)	1257393..1257824	+	432	WP_167395599.1	YcgN family cysteine cluster protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14758.20 Da
• Isoelectric Point: 4.6908

>T215467 WP_006996056.1 NZ_CP082857:1253215-1253607 [Haemophilus aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFEFVPNLILENWCSV

Nucleotide

• Length: 393 bp

>T215467 NZ_CP110775:c4595552-4595334 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10301.56 Da
• Isoelectric Point: 4.9010

>AT215467 WP_006996057.1 NZ_CP082857:1252954-1253214 [Haemophilus aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT215467 NZ_CP110775:c4595954-4595580 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C2R5S0