Detailed information of TA system TA215465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 195559..196207
• Replicon: chromosome
• Accession: NZ_CP082857
• Organism: Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: K8O83_RS01205
• Protein ID: WP_005694481.1
• Coordinates: 195559..195918 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: K8O83_RS01210
• Protein ID: WP_005650837.1
• Coordinates: 195911..196207 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O83_RS01175	192281..192331	+	51	Protein_218	PT domain-containing protein	-
K8O83_RS01195	192386..192772	+	387	Protein_219	TonB-dependent receptor plug domain-containing protein	-
K8O83_RS01200 (K8O83_01170)	192980..195298	+	2319	WP_223395620.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K8O83_RS01205 (K8O83_01175)	195559..195918	+	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8O83_RS01210 (K8O83_01180)	195911..196207	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
K8O83_RS01215 (K8O83_01185)	196368..198284	+	1917	WP_006995317.1	ABC transporter ATP-binding protein	-
K8O83_RS01220 (K8O83_01190)	198294..198830	+	537	WP_006995316.1	type I DNA topoisomerase	-
K8O83_RS01225 (K8O83_01195)	198846..199397	+	552	WP_006995315.1	Sua5/YciO/YrdC/YwlC family protein	-
K8O83_RS01230 (K8O83_01200)	199401..200207	+	807	WP_006995314.1	shikimate dehydrogenase	-
K8O83_RS01235 (K8O83_01205)	200219..200971	+	753	WP_006995313.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T215465 WP_005694481.1 NZ_CP082857:195559-195918 [Haemophilus aegyptius]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T215465 NZ_CP110775:3869808-3870092 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGACAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT215465 WP_005650837.1 NZ_CP082857:195911-196207 [Haemophilus aegyptius]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT215465 NZ_CP110775:3869576-3869818 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0