Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 195559..196207 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag K8O83_RS01205 Protein ID WP_005694481.1
Coordinates 195559..195918 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag K8O83_RS01210 Protein ID WP_005650837.1
Coordinates 195911..196207 (+) Length 99 a.a.

Genomic Context

K8O83_RS01175K8O83_RS01195K8O83_RS01200K8O83_RS01205K8O83_RS01210K8O83_RS01215K8O83_RS01220K8O83_RS01225K8O83_RS01230K8O83_RS01235
Location: 192281..192331 (51 bp)
Type: Others
Protein ID: Protein_218
Location: 192386..192772 (387 bp)
Type: Others
Protein ID: Protein_219
Location: 192980..195298 (2319 bp)
Type: Others
Protein ID: WP_223395620.1
Location: 195559..195918 (360 bp)
Type: Toxin
Protein ID: WP_005694481.1
Location: 195911..196207 (297 bp)
Type: Antitoxin
Protein ID: WP_005650837.1
Location: 196368..198284 (1917 bp)
Type: Others
Protein ID: WP_006995317.1
Location: 198294..198830 (537 bp)
Type: Others
Protein ID: WP_006995316.1
Location: 198846..199397 (552 bp)
Type: Others
Protein ID: WP_006995315.1
Location: 199401..200207 (807 bp)
Type: Others
Protein ID: WP_006995314.1
Location: 200219..200971 (753 bp)
Type: Others
Protein ID: WP_006995313.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8O83_RS01175192281..192331+51Protein_218PT domain-containing protein-
K8O83_RS01195192386..192772+387Protein_219TonB-dependent receptor plug domain-containing protein-
K8O83_RS01200 (K8O83_01170)192980..195298+2319WP_223395620.1TonB-dependent hemoglobin/transferrin/lactoferrin family receptor-
K8O83_RS01205 (K8O83_01175)195559..195918+360WP_005694481.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K8O83_RS01210 (K8O83_01180)195911..196207+297WP_005650837.1helix-turn-helix transcriptional regulatorAntitoxin
K8O83_RS01215 (K8O83_01185)196368..198284+1917WP_006995317.1ABC transporter ATP-binding protein-
K8O83_RS01220 (K8O83_01190)198294..198830+537WP_006995316.1type I DNA topoisomerase-
K8O83_RS01225 (K8O83_01195)198846..199397+552WP_006995315.1Sua5/YciO/YrdC/YwlC family protein-
K8O83_RS01230 (K8O83_01200)199401..200207+807WP_006995314.1shikimate dehydrogenase-
K8O83_RS01235 (K8O83_01205)200219..200971+753WP_006995313.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T215465 WP_005694481.1 NZ_CP082857:195559-195918 [Haemophilus aegyptius]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

>T215465 NZ_CP110775:3869808-3870092 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGACAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT215465 WP_005650837.1 NZ_CP082857:195911-196207 [Haemophilus aegyptius]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp

>AT215465 NZ_CP110775:3869576-3869818 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Y7JUP0

Antitoxin

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Source
ID
Structure
No matching records found

References