Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1224395..1225026 Replicon chromosome
Accession NZ_CP082856
Organism Haemophilus influenzae strain FDAARGOS_1479

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag K8P04_RS06165 Protein ID WP_005651560.1
Coordinates 1224395..1224793 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X4XKC3
Locus tag K8P04_RS06170 Protein ID WP_015701961.1
Coordinates 1224793..1225026 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P04_RS06145 (K8P04_06080) 1219579..1220697 + 1119 WP_015701957.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
K8P04_RS06150 (K8P04_06085) 1220698..1221720 + 1023 WP_015701958.1 outer membrane-stress sensor serine endopeptidase DegS -
K8P04_RS06155 (K8P04_06090) 1221794..1222609 - 816 WP_015701959.1 DNA-formamidopyrimidine glycosylase -
K8P04_RS06160 (K8P04_06095) 1222840..1224375 - 1536 WP_015701960.1 L-2,4-diaminobutyrate decarboxylase -
K8P04_RS06165 (K8P04_06100) 1224395..1224793 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
K8P04_RS06170 (K8P04_06105) 1224793..1225026 - 234 WP_015701961.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K8P04_RS06175 (K8P04_06110) 1225173..1226537 - 1365 WP_015701962.1 diaminobutyrate--2-oxoglutarate transaminase -
K8P04_RS06180 (K8P04_06115) 1226884..1227054 - 171 WP_005613503.1 50S ribosomal protein L33 -
K8P04_RS06185 (K8P04_06120) 1227066..1227302 - 237 WP_005542826.1 50S ribosomal protein L28 -
K8P04_RS06190 (K8P04_06125) 1227516..1228181 - 666 WP_013527272.1 DNA repair protein RadC -
K8P04_RS06195 (K8P04_06130) 1228344..1229546 + 1203 WP_015701964.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T215462 WP_005651560.1 NZ_CP082856:c1224793-1224395 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T215462 NZ_CP110775:c3236737-3236375 [Citrobacter freundii]
ATGTGGGAAGTGGAAACAACGGATGCTTTCGATAAATGGTTTGACGTACAGACCGAAGCGCTCAAGGAAGATATGCTCGC
AGCAATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGCAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTACAGCATCAGGGTAGTCCGATTCGGGCGTTCTTCGCGTTTGATCCTTCTCGCCATGGCATC
GTGCTATGCGCTGGAGATAAAACAGGGTTAAACGAAAAGAAATTCTATAAAGAGATGATCAGGCTTGCGGATGCTGAGTA
CCGAAATCACCTAATAAGTAAGGAAAATTATGGCTACCCTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8911.01 Da        Isoelectric Point: 4.4013

>AT215462 WP_015701961.1 NZ_CP082856:c1225026-1224793 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQTVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT215462 NZ_CP110775:c3236388-3236089 [Citrobacter freundii]
ATGGCTACCCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGTATTACCGAAAAAGTAGAAATACTACG
TCAGGCGGTTGCGTTAAATATGTTAAGGGAAGAACTGAATCTCTCTCAGGCTGAACTTGCCTCGGCAATGGGGGTTAAGC
AGCCAACAATCGCAAAAATGGAGCAGGCAGATAACGATCCTCGTCTGTCGACGCTCAAGCGTTATGTCACGGCACTGGGT
GGTGAACTTAGCATTGATGTTAAGCTACCTACAGGTAAAAGAGTCGCGTTCTATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XKC3

References