Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1195886..1196420 Replicon chromosome
Accession NZ_CP082856
Organism Haemophilus influenzae strain FDAARGOS_1479

Toxin (Protein)


Gene name relE Uniprot ID Q849T7
Locus tag K8P04_RS06015 Protein ID WP_015701940.1
Coordinates 1195886..1196176 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4XNI1
Locus tag K8P04_RS06020 Protein ID WP_015701941.1
Coordinates 1196166..1196420 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P04_RS06000 (K8P04_05935) 1193287..1193790 + 504 WP_015701938.1 LPS assembly lipoprotein LptE -
K8P04_RS06005 (K8P04_05940) 1193790..1194824 + 1035 WP_015701939.1 DNA polymerase III subunit delta -
K8P04_RS06010 (K8P04_05945) 1195292..1195429 - 138 WP_172451690.1 hypothetical protein -
K8P04_RS06015 (K8P04_05950) 1195886..1196176 - 291 WP_015701940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8P04_RS06020 (K8P04_05955) 1196166..1196420 - 255 WP_015701941.1 stability protein StbD Antitoxin
K8P04_RS06025 (K8P04_05960) 1196511..1196717 - 207 WP_041175054.1 hypothetical protein -
K8P04_RS06030 (K8P04_05965) 1196726..1196950 - 225 WP_015701942.1 hypothetical protein -
K8P04_RS06035 (K8P04_05970) 1196950..1197201 - 252 WP_015701943.1 P2 family phage major capsid protein -
K8P04_RS06045 (K8P04_05980) 1197778..1199844 - 2067 WP_015701944.1 glycine--tRNA ligase subunit beta -
K8P04_RS06050 (K8P04_05985) 1200181..1200546 - 366 WP_015701945.1 endonuclease domain-containing protein -
K8P04_RS06055 (K8P04_05990) 1200576..1200836 - 261 WP_005651528.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11496.44 Da        Isoelectric Point: 10.6484

>T215461 WP_015701940.1 NZ_CP082856:c1196176-1195886 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSIGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T215461 NZ_CP110775:c2985701-2985426 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9449.81 Da        Isoelectric Point: 4.0737

>AT215461 WP_015701941.1 NZ_CP082856:c1196420-1196166 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELSRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT215461 NZ_CP110775:c2985429-2985070 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q849T7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XNI1

References