Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 972423..973027 Replicon chromosome
Accession NZ_CP082856
Organism Haemophilus influenzae strain FDAARGOS_1479

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag K8P04_RS04885 Protein ID WP_050948779.1
Coordinates 972719..973027 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag K8P04_RS04880 Protein ID WP_005692346.1
Coordinates 972423..972719 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P04_RS04865 (K8P04_04820) 968189..969574 + 1386 WP_077643972.1 L-seryl-tRNA(Sec) selenium transferase -
K8P04_RS04870 (K8P04_04825) 969571..971430 + 1860 WP_077643973.1 selenocysteine-specific translation elongation factor -
K8P04_RS04875 (K8P04_04830) 971449..972303 + 855 WP_070828147.1 DUF3298 domain-containing protein -
K8P04_RS04880 (K8P04_04835) 972423..972719 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8P04_RS04885 (K8P04_04840) 972719..973027 + 309 WP_050948779.1 type II toxin-antitoxin system YafQ family toxin Toxin
K8P04_RS04890 (K8P04_04845) 973084..976074 - 2991 WP_077643974.1 TonB-dependent receptor -
K8P04_RS04905 976133..976291 - 159 WP_238144389.1 PT domain-containing protein -
K8P04_RS04910 (K8P04_04850) 976592..977890 + 1299 WP_006995277.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T215460 WP_050948779.1 NZ_CP082856:972719-973027 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T215460 NZ_CP110775:2903556-2903873 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT215460 WP_005692346.1 NZ_CP082856:972423-972719 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT215460 NZ_CP110775:2903926-2904222 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References