Detailed information of TA system TA215458

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 914056..914704
• Replicon: chromosome
• Accession: NZ_CP082856
• Organism: Haemophilus influenzae strain FDAARGOS_1479

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: -
• Locus tag: K8P04_RS04595
• Protein ID: WP_077643740.1
• Coordinates: 914345..914704 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: K8P04_RS04590
• Protein ID: WP_005650837.1
• Coordinates: 914056..914352 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8P04_RS04565 (K8P04_04535)	909283..909846	-	564	WP_077643735.1	DNA-3-methyladenine glycosylase I	-
K8P04_RS04570 (K8P04_04540)	910060..910866	-	807	WP_077643736.1	shikimate dehydrogenase	-
K8P04_RS04575 (K8P04_04545)	910870..911421	-	552	WP_077643737.1	Sua5/YciO/YrdC/YwlC family protein	-
K8P04_RS04580 (K8P04_04550)	911437..911973	-	537	WP_077643738.1	type I DNA topoisomerase	-
K8P04_RS04585 (K8P04_04555)	911983..913899	-	1917	WP_077643739.1	ABC transporter ATP-binding protein	-
K8P04_RS04590 (K8P04_04560)	914056..914352	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
K8P04_RS04595 (K8P04_04565)	914345..914704	-	360	WP_077643740.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8P04_RS04600 (K8P04_04570)	914974..917241	-	2268	WP_223364827.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K8P04_RS04605	917443..917850	-	408	Protein_853	TonB-dependent receptor plug domain-containing protein	-
K8P04_RS04610	917798..917926	-	129	WP_223267139.1	PT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14287.65 Da
• Isoelectric Point: 10.1408

>T215458 WP_077643740.1 NZ_CP082856:c914704-914345 [Haemophilus influenzae]
MYEILLYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T215458 NZ_CP110775:c1122698-1122595 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT215458 WP_005650837.1 NZ_CP082856:c914352-914056 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT215458 NZ_CP110775:1122590-1122733 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT