Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 116200..116734 Replicon plasmid unnamed3
Accession NZ_CP082855
Organism Legionella anisa strain FDAARGOS_1480

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag K8O89_RS19965 Protein ID WP_014845122.1
Coordinates 116200..116481 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag K8O89_RS19970 Protein ID WP_014845121.1
Coordinates 116474..116734 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O89_RS19940 (K8O89_19850) 111619..111942 + 324 WP_014845127.1 hypothetical protein -
K8O89_RS19945 (K8O89_19855) 111995..112813 + 819 WP_014845126.1 hypothetical protein -
K8O89_RS19950 (K8O89_19860) 112852..113205 + 354 WP_014845125.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8O89_RS19955 (K8O89_19865) 113183..113473 + 291 WP_014845124.1 helix-turn-helix transcriptional regulator -
K8O89_RS19960 (K8O89_19870) 113522..116020 + 2499 WP_014845123.1 helicase C-terminal domain-containing protein -
K8O89_RS19965 (K8O89_19875) 116200..116481 - 282 WP_014845122.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K8O89_RS19970 (K8O89_19880) 116474..116734 - 261 WP_014845121.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K8O89_RS19975 (K8O89_19885) 116947..117831 + 885 WP_014845120.1 recombinase family protein -
K8O89_RS19980 (K8O89_19890) 117958..118284 + 327 WP_014845119.1 hypothetical protein -
K8O89_RS19985 (K8O89_19895) 118390..118626 + 237 WP_223499713.1 hypothetical protein -
K8O89_RS19990 (K8O89_19900) 118613..118933 + 321 WP_014845117.1 type II toxin-antitoxin system PemK/MazF family toxin -
K8O89_RS19995 (K8O89_19905) 119371..119859 - 489 WP_014845116.1 class I SAM-dependent methyltransferase -
K8O89_RS20000 (K8O89_19910) 120129..120662 - 534 WP_061637559.1 IS91 family transposase -
K8O89_RS20010 (K8O89_19920) 121247..121402 + 156 WP_154080667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..143699 143699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T215456 WP_014845122.1 NZ_CP082855:c116481-116200 [Legionella anisa]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T215456 NZ_CP110774:c1888924-1888523 [Acidocella sp. MX-AZ03]
ATGTTGCGTTACATGCTCGATACCAACCTCTGCATCCGTGTGCTCAGGGATCGTCCGCAGGGGGTGAGGGCACGCTTCAA
TGCTAATGCCGAAGCCTTATGCCTTTCGGATGTGGTTCTCTATGAATTGCTTTATGGCGCTGAGCGTTCGAACGATCCAC
CACGCATCCGTCGCGAGGTCGAGCATTTTGCGGGGCGCCTGACAGTGCTGCCTTTCGACAGTGAGGCGGCGGCCCATACA
GCTGAGATATGCGGCGATCTTAAACGGCGAGGCAATGTCATCGGCCCCTACGATCTGATGATCGCCGGTCATGCACGCAG
CAAAGGCTTGATTATCGTCACAGGTAATCTGGGGGAGTTCCAGCGTGTTTTGGGGGTAAGGTCTGAAGACTGGCTGGTAT
AG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT215456 WP_014845121.1 NZ_CP082855:c116734-116474 [Legionella anisa]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT215456 NZ_CP110774:c1889148-1888924 [Acidocella sp. MX-AZ03]
ATGCTCGCGCGAACATCACTCTTTCTCTCCAACCGCTCGCAGGCTGTGCGGTTGCCCAAGGCGGTGGCATTTTCCGAGGG
GGTGCGCGAGGTGGTCATCGTTCCCGACGGCCCGCGCCGGATCATCGCGCCCGCCGAAGCGGCTTGGGATGATTTCTTTG
ACGCGCCGGGGATTGATCTTGGCGAGCGTGTCCAGCCAATGGCGCAGGAGCGTGAGCATTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G4RL39

Antitoxin

Source ID Structure
AlphaFold DB A0A7G4RL40

References