Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1029..1627 Replicon plasmid unnamed2
Accession NZ_CP082854
Organism Legionella anisa strain FDAARGOS_1480

Toxin (Protein)


Gene name hicA Uniprot ID A0A2Z3L5E4
Locus tag K8O89_RS19080 Protein ID WP_019232989.1
Coordinates 1029..1226 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2Z3KTJ8
Locus tag K8O89_RS19085 Protein ID WP_019232990.1
Coordinates 1223..1627 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O89_RS19075 (K8O89_18995) 533..859 + 327 WP_019232988.1 hypothetical protein -
K8O89_RS19080 (K8O89_19000) 1029..1226 + 198 WP_019232989.1 type II toxin-antitoxin system HicA family toxin Toxin
K8O89_RS19085 (K8O89_19005) 1223..1627 + 405 WP_019232990.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K8O89_RS19090 (K8O89_19010) 1642..2964 - 1323 WP_019232991.1 DUF1186 domain-containing protein -
K8O89_RS19095 (K8O89_19015) 3128..3490 + 363 WP_019232992.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8O89_RS19100 (K8O89_19020) 3483..3788 + 306 WP_019232993.1 helix-turn-helix domain-containing protein -
K8O89_RS19105 (K8O89_19025) 4101..4337 - 237 WP_080480132.1 hypothetical protein -
K8O89_RS19110 (K8O89_19030) 4349..4606 - 258 WP_127908205.1 hypothetical protein -
K8O89_RS19115 (K8O89_19035) 4622..4918 - 297 WP_019232994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48353 48353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7401.77 Da        Isoelectric Point: 10.6519

>T215453 WP_019232989.1 NZ_CP082854:1029-1226 [Legionella anisa]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPAKKGRVTVPHPKKDLPIKTVVSIFKQAGINKEDIK

Download         Length: 198 bp

>T215453 NZ_CP110774:70975-71376 [Acidocella sp. MX-AZ03]
ATGTTGCGCTATATGCTGGACACCAACCTCTGCATCCGTGTGCTCAGGGATCGGCCGCAGGAGGTGAGGACGCGCTTCAA
TGCTAATGCCGAAGCCTTATGCCTTTCGGATGTGGTTCTCTATGAATTGCTTTATGGCGCTGAGCGTTCGAACGATCCGC
CGCGCATCCGCCGCGAGGTCGAGCATTTTGCTGGGCGCCTGACGGTGCTGCCTTTCGACAGTGAGGCGGCGGCCCATACC
GCCGAGATACGCGGCGATCTTGAGCGGCTGGGTAATGTGATCGGACCATATGATCTGATGATCGCCGGCCATGCGCGCAG
CAGAGGCTTGATCGTCGTCACAGGTAATCTTGGCGAATTCCAGCGTGTGTTGGGGTTAAGGTCTGAAGACTGGCTGGAAT
AG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14964.88 Da        Isoelectric Point: 4.4085

>AT215453 WP_019232990.1 NZ_CP082854:1223-1627 [Legionella anisa]
MRYPVVIHKDEQSDFGVSIPDIPGCYSAGSTYDEALTNAIEAIECHLEGLLMDNESLPVGTTIDRWINDEEFQGGVWAFI
DIDLSQISGKAKRINITMPERVLSLIDLYAKNHSIKNRSSFLADAALSYMESHK

Download         Length: 405 bp

>AT215453 NZ_CP110774:70751-70975 [Acidocella sp. MX-AZ03]
ATGCTCGCGCGAACATCACTCTTTCTCTCCAACCGCTCGCAGGCTGTGCGGTTGCCGAAGGCGGTGGCATTTTCCGAGGG
AGTGCACGAGGTGGTCATCGTTCCCGACGGCCCGCGCCGGATCATCGCGCCCGCCGAAGCGGCTTGGGATGATTTCTTTG
ACGCGCCGGGGATTGATCTGGGCGAGCGTGTGCAGCCGGTGGCGCAGGAGCGCGAGCGTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3L5E4

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3KTJ8

References