Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 412189..413741 Replicon chromosome
Accession NZ_CP082852
Organism Legionella anisa strain FDAARGOS_1480

Toxin (Protein)


Gene name hipA Uniprot ID A0A2Z3KPA6
Locus tag K8O89_RS01835 Protein ID WP_019233310.1
Coordinates 412434..413741 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2Z3KPE8
Locus tag K8O89_RS01830 Protein ID WP_019233311.1
Coordinates 412189..412440 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O89_RS01805 (K8O89_01810) 407195..407794 + 600 WP_019233316.1 LysE family translocator -
K8O89_RS01810 (K8O89_01815) 407905..409371 + 1467 WP_019233315.1 catalase -
K8O89_RS01815 (K8O89_01820) 409631..409921 + 291 WP_019233314.1 hypothetical protein -
K8O89_RS01820 (K8O89_01825) 410130..411035 - 906 WP_019233313.1 DMT family transporter -
K8O89_RS01825 (K8O89_01830) 411319..412023 + 705 WP_019233312.1 hypothetical protein -
K8O89_RS01830 (K8O89_01835) 412189..412440 + 252 WP_019233311.1 helix-turn-helix domain-containing protein Antitoxin
K8O89_RS01835 (K8O89_01840) 412434..413741 + 1308 WP_019233310.1 HipA domain-containing protein Toxin
K8O89_RS01840 (K8O89_01845) 413894..414769 + 876 WP_019233309.1 polysaccharide deacetylase family protein -
K8O89_RS01845 (K8O89_01850) 415247..416461 - 1215 WP_040522430.1 murein transglycosylase A -
K8O89_RS01850 (K8O89_01855) 416785..417456 - 672 WP_223499467.1 type II secretion system protein -
K8O89_RS01855 (K8O89_01860) 417453..418196 - 744 WP_019233305.1 hypothetical protein -
K8O89_RS01860 (K8O89_01865) 418193..418576 - 384 WP_223499469.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(152-401)

Antitoxin

(13-64)


Sequences


Toxin        


Download         Length: 436 a.a.        Molecular weight: 49982.72 Da        Isoelectric Point: 7.9915

>T215451 WP_019233310.1 NZ_CP082852:412434-413741 [Legionella anisa]
MVKKNQILYVLMNGILVGMLEKTSQGGLKFTYHQDWLNQAGARPISLSLPLVEQTYAGDVVYNFFDNLLPDNQQIRARIQ
ARFQIATSQPFDLLAGIGRDCVGAIQLITGPLAEFERKIKYKPLTEQKIASILRNYQINPLGMSQEEEEFRISIAGAQEK
TAFLYHENQWCEPLQETPTTHIFKLPIGIIAHQHMDLRDSCENEWLCSLLAKSYGLPAADCDILHFEEIKVLSVKRFDRR
LSRDNSWIMRLPQEDLCQALGVSYNIKYQSDGGPGIKEIMKLLLGSANSLPDRDMFYRAQVFFWLIAGIDGHAKNFSLFI
EPEGKYRLTPLYDIMSAYPLIKKNQLQTQKIKMAMALKGKNTHYHWHTLQRRHFIDTAKEANYSPERAEIILNEMLKQTD
SVIQEVSKKLPPSFPNTISEPIFEGLRKTKQKLEE

Download         Length: 1308 bp

>T215451 NZ_CP110680:c214353-213919 [Cellulomonas fimi]
GTGATCCTGCCTGACGTCAACGTGCTCGTCGGGGCCGCCCGCGCGGATGCGCCACAGCACGCGAGGCTGCGCACCTGGGT
GGAGCAGCACGTCCCCGGACCGGAGACCTTCGGCCTCACCGACGCCGTCCTCGGCGGGGTCGTGCGCGTCCTCACCCACC
CGCGCGTGTTCGTCCGACCGTCGACGCTCGACGAGGCACTCGGGTTCGTCGACGCCCTGGTCGCGCATCCCAACGTCTCG
CGCGTGACGCCCGGACCACGCCACTGGCAGCTCGTCGCCGAGCTCTGCCGGGCCGCCGACGCTCGCGGCAACCTCGTCGC
CGACGCGCAGCATGCCGCCGTCGCGATCGAGCACGGCGCGACGTGGGTGTCACAGGATCGCGACTTCGCACGCTTCCCCG
GCCTGCGCTGGGTGACGGCCGTCGAACCCGGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9413.91 Da        Isoelectric Point: 9.9528

>AT215451 WP_019233311.1 NZ_CP082852:412189-412440 [Legionella anisa]
MLIHSSLELALLIKNQRKKLKLSQAEVAALVGLKQKTISAIENNPEHMRLSTLFRILSALDLDLKISAKSESNTTNNQWN
DEW

Download         Length: 252 bp

>AT215451 NZ_CP110680:c214592-214350 [Cellulomonas fimi]
GTGCGTACGACGCTGCTGCTGCCCGACGACCTCTATCGCGAGGTGAAGTCCACCGCCGCCGCCTCTGGCGAGACGATGAC
GTCGTTCGTCGAGGAGGCGCTGCGGGAGGCGCTGCGTCGCCGCGCGAGAGCCGGGCATGCCGCGGTCGACTTCGTCGTCG
CGCCGACCGGCTCCGGCGGCCTGCAGCCCGGTGTCGAGCTCGACGACAGCGCGGCACTGCTCGACGTGATGGACGCCCGG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2Z3KPA6


Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3KPE8

References