Detailed information of TA system TA215449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 2778451..2778991
• Replicon: chromosome
• Accession: NZ_CP082848
• Organism: Legionella pneumophila strain FDAARGOS_1482

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: K8O97_RS12515
• Protein ID: WP_014844324.1
• Coordinates: 2778695..2778991 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: K8O97_RS12510
• Protein ID: WP_027224835.1
• Coordinates: 2778451..2778705 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O97_RS12475 (K8O97_12445)	2774113..2774991	+	879	WP_027224831.1	hypothetical protein	-
K8O97_RS12495 (K8O97_12465)	2775524..2776699	-	1176	WP_027224832.1	ISL3 family transposase	-
K8O97_RS12500 (K8O97_12470)	2776854..2777432	+	579	WP_027224833.1	hypothetical protein	-
K8O97_RS12505 (K8O97_12475)	2777537..2778103	+	567	WP_027224834.1	hypothetical protein	-
K8O97_RS12510 (K8O97_12480)	2778451..2778705	+	255	WP_027224835.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
K8O97_RS12515 (K8O97_12485)	2778695..2778991	+	297	WP_014844324.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8O97_RS12520 (K8O97_12490)	2779452..2780405	-	954	WP_223380970.1	integrase core domain-containing protein	-
K8O97_RS12525 (K8O97_12495)	2780729..2780938	+	210	WP_010947832.1	cold-shock protein	-
K8O97_RS12530 (K8O97_12500)	2781178..2782584	+	1407	WP_014844326.1	ATP-dependent RNA helicase DbpA	-
K8O97_RS12535 (K8O97_12505)	2782741..2783652	+	912	WP_014844327.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2775524..2776699	1175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-81)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11582.28 Da
• Isoelectric Point: 7.2728

>T215449 WP_014844324.1 NZ_CP082848:2778695-2778991 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Nucleotide

• Length: 297 bp

>T215449 NZ_CP110679:2806705-2806971 [Sphingomonas sp. S6-11]
GTGAAGATCGTCTTCTGGCCAACCGCCTTGGAGGATTATCTCCATTGGCAGGCCGAAGACACGCGGTTGCTGGAGCGCGT
GAACGCGCTACTCAAGGAGTGCCGGCGCGATCCTTTTCGTGGGCTGGGCAAGCCGGAGCCCCTGGGCAAAAACATGTCCT
GCTGGTGGTCCCGCCGGATCGATCGCGAGCACCGGCTGGTGTATCGCGTGACGGGGAGCGGCGAGGCACAGACCGTGGAA
GTGGCGCAGTGCCGGTATCATTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9786.14 Da
• Isoelectric Point: 9.9613

>AT215449 WP_027224835.1 NZ_CP082848:2778451-2778705 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Nucleotide

• Length: 255 bp

>AT215449 NZ_CP110679:2806439-2806708 [Sphingomonas sp. S6-11]
TTGTACATAGAATATATCGAAATTCTCAGCACTTCCGAAGCCCGGGCGAACATCAAGGCGGTGATGGACCGCGTCGTTGC
CAACCGCGCGCCGATCGGCATCTCGCGTCCAAAGGGCGAGGGGGTGGTGATGGTCTCGCAGAGCGAGTGGGATTCGATCG
AGGAGACGATGTATCTGCTGGCGTCGCCCAAGAATGCTGAGCGCTTGCTGGAAGCGATCCGGGGGCTGCAGGCTGGCGGA
GGCGAAGAGCACGAACTGATCGATCCGTGA