Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2778451..2778991 Replicon chromosome
Accession NZ_CP082848
Organism Legionella pneumophila strain FDAARGOS_1482

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag K8O97_RS12515 Protein ID WP_014844324.1
Coordinates 2778695..2778991 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag K8O97_RS12510 Protein ID WP_027224835.1
Coordinates 2778451..2778705 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O97_RS12475 (K8O97_12445) 2774113..2774991 + 879 WP_027224831.1 hypothetical protein -
K8O97_RS12495 (K8O97_12465) 2775524..2776699 - 1176 WP_027224832.1 ISL3 family transposase -
K8O97_RS12500 (K8O97_12470) 2776854..2777432 + 579 WP_027224833.1 hypothetical protein -
K8O97_RS12505 (K8O97_12475) 2777537..2778103 + 567 WP_027224834.1 hypothetical protein -
K8O97_RS12510 (K8O97_12480) 2778451..2778705 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K8O97_RS12515 (K8O97_12485) 2778695..2778991 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8O97_RS12520 (K8O97_12490) 2779452..2780405 - 954 WP_223380970.1 integrase core domain-containing protein -
K8O97_RS12525 (K8O97_12495) 2780729..2780938 + 210 WP_010947832.1 cold-shock protein -
K8O97_RS12530 (K8O97_12500) 2781178..2782584 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
K8O97_RS12535 (K8O97_12505) 2782741..2783652 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2775524..2776699 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T215449 WP_014844324.1 NZ_CP082848:2778695-2778991 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

>T215449 NZ_CP110679:2806705-2806971 [Sphingomonas sp. S6-11]
GTGAAGATCGTCTTCTGGCCAACCGCCTTGGAGGATTATCTCCATTGGCAGGCCGAAGACACGCGGTTGCTGGAGCGCGT
GAACGCGCTACTCAAGGAGTGCCGGCGCGATCCTTTTCGTGGGCTGGGCAAGCCGGAGCCCCTGGGCAAAAACATGTCCT
GCTGGTGGTCCCGCCGGATCGATCGCGAGCACCGGCTGGTGTATCGCGTGACGGGGAGCGGCGAGGCACAGACCGTGGAA
GTGGCGCAGTGCCGGTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT215449 WP_027224835.1 NZ_CP082848:2778451-2778705 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp

>AT215449 NZ_CP110679:2806439-2806708 [Sphingomonas sp. S6-11]
TTGTACATAGAATATATCGAAATTCTCAGCACTTCCGAAGCCCGGGCGAACATCAAGGCGGTGATGGACCGCGTCGTTGC
CAACCGCGCGCCGATCGGCATCTCGCGTCCAAAGGGCGAGGGGGTGGTGATGGTCTCGCAGAGCGAGTGGGATTCGATCG
AGGAGACGATGTATCTGCTGGCGTCGCCCAAGAATGCTGAGCGCTTGCTGGAAGCGATCCGGGGGCTGCAGGCTGGCGGA
GGCGAAGAGCACGAACTGATCGATCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References