215443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4901018..4901601 Replicon chromosome
Accession NZ_CP082846
Organism Mycolicibacterium smegmatis strain FDAARGOS_1484

Toxin (Protein)


Gene name doc Uniprot ID A0A2U9PKR4
Locus tag K8P01_RS23405 Protein ID WP_003892660.1
Coordinates 4901212..4901601 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag K8P01_RS23400 Protein ID WP_011727559.1
Coordinates 4901018..4901215 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P01_RS23380 (K8P01_23310) 4896931..4898010 - 1080 WP_058125481.1 HNH endonuclease domain-containing protein -
K8P01_RS23385 (K8P01_23315) 4898119..4899192 - 1074 WP_223495413.1 SMP-30/gluconolactonase/LRE family protein -
K8P01_RS23390 (K8P01_23320) 4899427..4900506 - 1080 WP_058125483.1 HNH endonuclease domain-containing protein -
K8P01_RS23395 (K8P01_23325) 4900574..4900870 + 297 WP_003892658.1 nucleoside triphosphate pyrophosphohydrolase -
K8P01_RS23400 (K8P01_23330) 4901018..4901215 + 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
K8P01_RS23405 (K8P01_23335) 4901212..4901601 + 390 WP_003892660.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K8P01_RS23410 (K8P01_23340) 4901678..4903108 + 1431 WP_058125484.1 DUF3375 domain-containing protein -
K8P01_RS23415 (K8P01_23345) 4903105..4903683 + 579 WP_038557632.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(18-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13868.49 Da        Isoelectric Point: 4.2481

>T215443 WP_003892660.1 NZ_CP082846:4901212-4901601 [Mycolicibacterium smegmatis]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAQTG

Download         Length: 390 bp

>T215443 NZ_CP110678:2168158-2168424 [Sphingomonas sp. S1-29]
TTGGCCTGGCGGATTGAGTTCCTGCCCGAGGCGGCGAAGGAACTGGCCAAGCTCGACCGCACCGCAGCGGCGCGGATCAT
CAAGACGTTGGAGACGCGGATCGCCGTGCAGGACGATCCACGTTCGCTGGGAAGCGCGCTGACGGGCGACCATGCGGGCT
ATTGGCGCTGGCGGATCGGCGACTATCGCGTGGTGGCGCGCATCGAGGATGACCGGGTGCTGATCCTGGTAGTGCGAGTG
GCGCATCGGCGCGAGGTGTATCGGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT215443 WP_011727559.1 NZ_CP082846:4901018-4901215 [Mycolicibacterium smegmatis]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp

>AT215443 NZ_CP110678:2167956-2168174 [Sphingomonas sp. S1-29]
ATGCTGGCAGTGCGATTGGATACCGAAACCGAGGCGCGGCTCGAAGCGCTCGCCGCGCGGACGGGGCGGACCAAGACCTT
CTATGCACGCGAGGCGATCGTCGCGCATCTCGACGATCTCGAGGATTTCTATCTGGCCGAGGAGCGACTGCGCGATTTCC
GCGACGGCGACGCGATCCCGCTTGCCGATCTGAAGGCGCAGCTTGGCCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKR4

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References