Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4195297..4195994 Replicon chromosome
Accession NZ_CP082846
Organism Mycolicibacterium smegmatis strain FDAARGOS_1484

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8P01_RS19980 Protein ID WP_081319354.1
Coordinates 4195297..4195728 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8P01_RS19985 Protein ID WP_058125156.1
Coordinates 4195737..4195994 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P01_RS19960 (K8P01_19910) 4191320..4192228 + 909 WP_058125151.1 MBL fold metallo-hydrolase -
K8P01_RS19965 (K8P01_19915) 4192221..4193612 + 1392 WP_058125152.1 carboxylesterase family protein -
K8P01_RS19970 (K8P01_19920) 4193669..4194301 - 633 WP_058125153.1 TetR/AcrR family transcriptional regulator -
K8P01_RS19975 (K8P01_19925) 4194380..4195285 + 906 WP_058125154.1 oxygenase MpaB family protein -
K8P01_RS19980 (K8P01_19930) 4195297..4195728 - 432 WP_081319354.1 type II toxin-antitoxin system VapC family toxin Toxin
K8P01_RS19985 (K8P01_19935) 4195737..4195994 - 258 WP_058125156.1 ribbon-helix-helix protein, CopG family Antitoxin
K8P01_RS19990 (K8P01_19940) 4196093..4196995 + 903 WP_058127516.1 class I SAM-dependent methyltransferase -
K8P01_RS19995 (K8P01_19945) 4197125..4198951 + 1827 WP_174519565.1 type VII secretion AAA-ATPase EccA -
K8P01_RS20000 (K8P01_19950) 4198948..4200504 + 1557 WP_058125158.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15939.08 Da        Isoelectric Point: 6.1461

>T215442 WP_081319354.1 NZ_CP082846:c4195728-4195297 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Download         Length: 432 bp

>T215442 NZ_CP110674:3829916-3830326 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9140.34 Da        Isoelectric Point: 5.8508

>AT215442 WP_058125156.1 NZ_CP082846:c4195994-4195737 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Download         Length: 258 bp

>AT215442 NZ_CP110674:3829641-3829919 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCTGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References