Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 7080650..7081293 Replicon chromosome
Accession NZ_CP082844
Organism Nocardia asteroides strain FDAARGOS_1485

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8O92_RS32300 Protein ID WP_159929849.1
Coordinates 7080901..7081293 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8O92_RS32295 Protein ID WP_159929801.1
Coordinates 7080650..7080904 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O92_RS32280 (K8O92_32010) 7076304..7077122 - 819 WP_223517195.1 PhzF family phenazine biosynthesis protein -
K8O92_RS32285 (K8O92_32015) 7077204..7079627 - 2424 WP_223517197.1 HAD-IC family P-type ATPase -
K8O92_RS32290 (K8O92_32020) 7079663..7080604 + 942 WP_195141403.1 EamA family transporter RarD -
K8O92_RS32295 (K8O92_32025) 7080650..7080904 + 255 WP_159929801.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8O92_RS32300 (K8O92_32030) 7080901..7081293 + 393 WP_159929849.1 type II toxin-antitoxin system VapC family toxin Toxin
K8O92_RS32305 (K8O92_32035) 7081434..7081931 - 498 WP_223517199.1 hypothetical protein -
K8O92_RS32310 (K8O92_32040) 7082125..7083453 - 1329 WP_263291566.1 DNA polymerase IV -
K8O92_RS32315 (K8O92_32045) 7083847..7084734 + 888 WP_201295378.1 UTP--glucose-1-phosphate uridylyltransferase -
K8O92_RS32320 (K8O92_32050) 7084942..7085484 - 543 WP_223517202.1 NlpC/P60 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14327.42 Da        Isoelectric Point: 4.9205

>T215438 WP_159929849.1 NZ_CP082844:7080901-7081293 [Nocardia asteroides]
VKAERALADTSIFIGLEAERFDPARFDGYEWGVSVITLGELRLGVLRAASPDVSARRLATYQLAKQFQPLELDEAVSEHW
ALLVARLRAAGRKVPINDSWIAATALAHDIPIVTQDGDYDAMPDLKVLKL

Download         Length: 393 bp

>T215438 NZ_CP110674:c3697719-3697324 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9696.12 Da        Isoelectric Point: 5.7186

>AT215438 WP_159929801.1 NZ_CP082844:7080650-7080904 [Nocardia asteroides]
MTALPARDLRNHTAEVLRRVEAGEEIEILKDNRPVAKIIPLPRRRQWVPAPEILRELVRLGPDTTGLHQDLRETLTDTTD
DLPW

Download         Length: 255 bp

>AT215438 NZ_CP110674:c3697973-3697719 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References