Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 612990..613543 Replicon chromosome
Accession NZ_CP082844
Organism Nocardia asteroides strain FDAARGOS_1485

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K8O92_RS02895 Protein ID WP_159930394.1
Coordinates 613286..613543 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K8O92_RS02890 Protein ID WP_083887396.1
Coordinates 612990..613289 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O92_RS02860 (K8O92_02860) 608514..609872 + 1359 WP_223518561.1 FAD-linked oxidase C-terminal domain-containing protein -
K8O92_RS02865 (K8O92_02865) 609919..610203 + 285 WP_195071607.1 GNAT family N-acetyltransferase -
K8O92_RS02870 (K8O92_02870) 610316..610513 - 198 WP_195071608.1 DUF397 domain-containing protein -
K8O92_RS02875 (K8O92_02875) 610510..611394 - 885 WP_195071645.1 helix-turn-helix transcriptional regulator -
K8O92_RS02880 (K8O92_02880) 611719..612150 + 432 WP_223518563.1 DNA-directed RNA polymerase subunit beta -
K8O92_RS02885 (K8O92_02885) 612494..612856 + 363 WP_223518565.1 hypothetical protein -
K8O92_RS02890 (K8O92_02890) 612990..613289 + 300 WP_083887396.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K8O92_RS02895 (K8O92_02895) 613286..613543 + 258 WP_159930394.1 Txe/YoeB family addiction module toxin Toxin
K8O92_RS02900 (K8O92_02900) 613700..614857 - 1158 WP_223518567.1 acyl-CoA dehydrogenase -
K8O92_RS02905 (K8O92_02905) 615022..615684 - 663 WP_159930404.1 TetR family transcriptional regulator -
K8O92_RS02910 (K8O92_02910) 615830..616873 - 1044 WP_223518568.1 hypothetical protein -
K8O92_RS02915 (K8O92_02915) 616908..617726 - 819 WP_236565765.1 RNA polymerase sigma-70 factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10131.56 Da        Isoelectric Point: 8.0538

>T215436 WP_159930394.1 NZ_CP082844:613286-613543 [Nocardia asteroides]
VKLTFTDPAWDDYQWWLANDKKILRRINTLIADIKRNGYEGIGKPEALKHHLAGYWSRRITTEHRIVYAIEDDSVVIIAC
RYHYE

Download         Length: 258 bp

>T215436 NZ_CP110674:3660483-3660866 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10479.57 Da        Isoelectric Point: 4.4098

>AT215436 WP_083887396.1 NZ_CP082844:612990-613289 [Nocardia asteroides]
MKPMTYTEARANFASVLDSATEDLEEVVITRAGHEPAVVVALSEYQALQETAYLLGSPANARHLERSIAEHRGGGATPRE
LVDVDEGSEGNVTPGKASA

Download         Length: 300 bp

>AT215436 NZ_CP110674:3660233-3660388 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References