Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1976940..1977600 Replicon chromosome
Accession NZ_CP082841
Organism Kluyvera sp. CRP

Toxin (Protein)


Gene name cptA Uniprot ID A0A6G9RIE7
Locus tag K7B04_RS09290 Protein ID WP_065355982.1
Coordinates 1977187..1977600 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1B7K5W2
Locus tag K7B04_RS09285 Protein ID WP_064542776.1
Coordinates 1976940..1977206 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B04_RS09260 (K7B04_09235) 1972185..1973618 - 1434 WP_223803876.1 6-phospho-beta-glucosidase BglA -
K7B04_RS09265 (K7B04_09240) 1973740..1974468 - 729 WP_065355987.1 MurR/RpiR family transcriptional regulator -
K7B04_RS09270 (K7B04_09245) 1974520..1974834 + 315 WP_065355986.1 N(4)-acetylcytidine aminohydrolase -
K7B04_RS09275 (K7B04_09250) 1974993..1975655 + 663 WP_223803877.1 hemolysin III family protein -
K7B04_RS09280 (K7B04_09255) 1975713..1976696 - 984 WP_223803878.1 tRNA-modifying protein YgfZ -
K7B04_RS09285 (K7B04_09260) 1976940..1977206 + 267 WP_064542776.1 FAD assembly factor SdhE Antitoxin
K7B04_RS09290 (K7B04_09265) 1977187..1977600 + 414 WP_065355982.1 protein YgfX Toxin
K7B04_RS09295 (K7B04_09270) 1977597..1978118 - 522 WP_064542782.1 flavodoxin FldB -
K7B04_RS09300 (K7B04_09275) 1978221..1979117 + 897 WP_064542785.1 site-specific tyrosine recombinase XerD -
K7B04_RS09305 (K7B04_09280) 1979140..1979853 + 714 WP_065355981.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K7B04_RS09310 (K7B04_09285) 1979859..1981592 + 1734 WP_223803879.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16377.35 Da        Isoelectric Point: 11.8921

>T215423 WP_065355982.1 NZ_CP082841:1977187-1977600 [Kluyvera sp. CRP]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
EWEILGAPWMLNSGMMLRIRRPGGRRQHLWLAADSMNPEEWRDLRRILLQQPAPTKH

Download         Length: 414 bp

>T215423 NZ_CP110674:c2845996-2845601 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10456.93 Da        Isoelectric Point: 4.6412

>AT215423 WP_064542776.1 NZ_CP082841:1976940-1977206 [Kluyvera sp. CRP]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKALFIRLLECDDPDLFNWLMNHGEPADASLQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215423 NZ_CP110674:c2845575-2845309 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9RIE7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7K5W2

References