Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1059613..1060235 Replicon chromosome
Accession NZ_CP082841
Organism Kluyvera sp. CRP

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K7B04_RS04915 Protein ID WP_223803599.1
Coordinates 1059613..1059984 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K7B04_RS04920 Protein ID WP_163448705.1
Coordinates 1059981..1060235 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B04_RS04900 (K7B04_04875) 1057115..1058017 + 903 WP_065357314.1 formate dehydrogenase subunit beta -
K7B04_RS04905 (K7B04_04880) 1058014..1058649 + 636 WP_064540466.1 formate dehydrogenase cytochrome b556 subunit -
K7B04_RS04910 (K7B04_04885) 1058646..1059575 + 930 WP_163448703.1 formate dehydrogenase accessory protein FdhE -
K7B04_RS04915 (K7B04_04890) 1059613..1059984 - 372 WP_223803599.1 type II toxin-antitoxin system VapC family toxin Toxin
K7B04_RS04920 (K7B04_04895) 1059981..1060235 - 255 WP_163448705.1 CopG family transcriptional regulator Antitoxin
K7B04_RS04925 (K7B04_04900) 1060434..1061348 + 915 WP_163448706.1 alpha/beta hydrolase -
K7B04_RS04930 (K7B04_04905) 1061375..1062316 - 942 WP_163448707.1 fatty acid biosynthesis protein FabY -
K7B04_RS04935 (K7B04_04910) 1062361..1062798 - 438 WP_064540478.1 D-aminoacyl-tRNA deacylase -
K7B04_RS04940 (K7B04_04915) 1062795..1063652 - 858 WP_163448709.1 virulence factor BrkB family protein -
K7B04_RS04945 (K7B04_04920) 1063646..1064245 - 600 WP_223803600.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13957.26 Da        Isoelectric Point: 7.4018

>T215421 WP_223803599.1 NZ_CP082841:c1059984-1059613 [Kluyvera sp. CRP]
MNGPVIFDTNILIDLFSGRVEAKNTLDLYPPQHAISLITWMEVMVGAKRFHQERRTRMALNAFEVIEISPEIAEKSVNLR
QEYGMKLPDAIILATAHIHRRELVTRNTKDFSGLPGVVVPYAL

Download         Length: 372 bp

>T215421 NZ_CP110674:2704820-2705260 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10012.39 Da        Isoelectric Point: 4.3272

>AT215421 WP_163448705.1 NZ_CP082841:c1060235-1059981 [Kluyvera sp. CRP]
MSMMAERDMGRILLDLSDEVIRRLDELKQQRNMPRAELLREAVEMYLEKQNQAEQAIAGALGIWQECEDDGVEFERKLRE
EWTR

Download         Length: 255 bp

>AT215421 NZ_CP110674:2704546-2704833 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References