Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 459059..459811 Replicon chromosome
Accession NZ_CP082841
Organism Kluyvera sp. CRP

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag K7B04_RS02105 Protein ID WP_210180485.1
Coordinates 459059..459412 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag K7B04_RS02110 Protein ID WP_223803409.1
Coordinates 459446..459811 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B04_RS02095 457357..457536 - 180 WP_223803408.1 hypothetical protein -
K7B04_RS02100 (K7B04_02085) 458144..458980 - 837 WP_210180486.1 DUF4942 domain-containing protein -
K7B04_RS02105 (K7B04_02090) 459059..459412 - 354 WP_210180485.1 TA system toxin CbtA family protein Toxin
K7B04_RS02110 (K7B04_02095) 459446..459811 - 366 WP_223803409.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K7B04_RS02115 (K7B04_02100) 459845..460066 - 222 WP_223803410.1 DUF987 domain-containing protein -
K7B04_RS02120 (K7B04_02105) 460075..460545 - 471 WP_223803411.1 DNA repair protein RadC -
K7B04_RS02125 (K7B04_02110) 460616..461437 - 822 WP_210180481.1 DUF932 domain-containing protein -
K7B04_RS02130 (K7B04_02115) 462044..462883 - 840 WP_210180478.1 hypothetical protein -
K7B04_RS02135 (K7B04_02120) 462943..463377 - 435 WP_068795348.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 458144..482943 24799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-110)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13261.21 Da        Isoelectric Point: 5.5235

>T215420 WP_210180485.1 NZ_CP082841:c459412-459059 [Kluyvera sp. CRP]
MHISTVPATVPVASLLSPVQVWQQLLTYLLEHHYGLTLNDTPFRDDSAIQEHIEAGITLADAVNFLVERYELLRTDRKGV
KWQEQAPFLTAIDILRARRAIGLMNINSSSTIPDFYL

Download         Length: 354 bp

>T215420 NZ_CP110674:c2644599-2644204 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13499.28 Da        Isoelectric Point: 5.5706

>AT215420 WP_223803409.1 NZ_CP082841:c459811-459446 [Kluyvera sp. CRP]
MQSTTLSGTSAESASCFQWGLIRNITPCFGARLVQEGNRLYFLADRAGFNGSFIDDEALRLDQVFPLIMKQLERMLTTGE
LDPRSQYCVTLHHNGLTCEADTLGSHGYVYIAIYPQSTVTR

Download         Length: 366 bp

>AT215420 NZ_CP110674:c2644841-2644596 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References