Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3901698..3903423 Replicon chromosome
Accession NC_007948
Organism Polaromonas sp. JS666

Toxin (Protein)


Gene name doc Uniprot ID Q126F1
Locus tag BPRO_RS18410 Protein ID WP_011484582.1
Coordinates 3902527..3903423 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q126F2
Locus tag BPRO_RS18405 Protein ID WP_011484581.1
Coordinates 3901698..3902534 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPRO_RS18385 3896912..3898399 - 1488 WP_011484577.1 aldehyde dehydrogenase -
BPRO_RS18390 3898411..3899214 - 804 WP_011484578.1 aspartate dehydrogenase -
BPRO_RS18395 3899226..3900896 - 1671 WP_011484579.1 thiamine pyrophosphate-binding protein -
BPRO_RS18400 3900889..3901686 - 798 WP_011484580.1 SDR family oxidoreductase -
BPRO_RS18405 3901698..3902534 - 837 WP_011484581.1 IclR family transcriptional regulator Antitoxin
BPRO_RS18410 3902527..3903423 - 897 WP_011484582.1 alpha/beta hydrolase Toxin
BPRO_RS18415 3903435..3903971 - 537 WP_011484583.1 cupin domain-containing protein -
BPRO_RS18420 3904022..3904792 - 771 WP_011484584.1 SDR family oxidoreductase -
BPRO_RS18425 3905072..3905668 + 597 Protein_3697 RraA family protein -
BPRO_RS18430 3905835..3906731 - 897 WP_011484586.1 c-type cytochrome -
BPRO_RS18435 3907038..3908249 + 1212 WP_049764145.1 DNA polymerase IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-282)

Antitoxin

Transcription regulator IclR, N-terminal

(18-68)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 31312.68 Da        Isoelectric Point: 6.2203

>T21541 WP_011484582.1 NC_007948:c3903423-3902527 [Polaromonas sp. JS666]
MNAVPRTADDLLQAPLALLDSRFPQRIVPLPSGAQVALRECGAPGEAPTVVLLHGISSGAASWSHAALLAGEQVHVMAWD
APGYGDSTPLRGDAPTDADYAARLHELLQAMGVRRCVLVGHSLGALMACAYARDLGADRVTRVVLISPAGGYGAAAQATT
RERVRNERRDALQMLGVAGLAERIPQRLLSPAADSAARAWVQWNTARLQPEGYLQAVELLCASDLGTSQGLAMPVEVHCG
DADVVTPPAACRVWADLYAAPFDLIKGAGHASPVEQPEAVARLITRAAMQPNGATHHE

Download         Length: 897 bp

>T21541 NC_007948:c3903423-3902527 [Polaromonas sp. JS666]
ATGAACGCCGTGCCCCGCACCGCTGACGATCTGCTGCAGGCGCCGCTCGCGCTGCTGGATAGTCGCTTTCCCCAGCGCAT
CGTGCCGCTGCCCTCGGGCGCGCAGGTGGCGCTGCGCGAATGCGGTGCGCCCGGCGAGGCGCCCACGGTTGTGCTGCTGC
ACGGCATCAGCTCCGGCGCTGCCTCATGGTCGCATGCGGCGCTGCTGGCCGGTGAGCAGGTGCATGTCATGGCGTGGGAT
GCCCCCGGCTATGGTGACTCCACCCCGCTTCGGGGCGATGCCCCCACGGACGCAGACTATGCGGCACGCCTGCATGAACT
GCTGCAGGCGATGGGCGTTCGCCGCTGCGTGCTGGTCGGCCATTCGCTGGGCGCGCTGATGGCTTGCGCCTACGCCCGCG
ATCTGGGTGCAGACCGCGTCACACGCGTGGTGCTCATCAGCCCGGCGGGCGGCTATGGCGCTGCCGCGCAGGCCACCACC
CGCGAGCGCGTGCGCAACGAGCGCCGCGATGCGCTGCAGATGCTGGGCGTGGCCGGCCTGGCAGAGCGCATCCCGCAGCG
CCTGCTCTCGCCGGCGGCAGACTCTGCGGCACGTGCCTGGGTGCAATGGAACACCGCCCGCCTGCAGCCCGAAGGCTACC
TGCAGGCCGTCGAGCTGCTGTGCGCCAGCGACCTGGGAACAAGCCAGGGTCTGGCCATGCCGGTGGAGGTTCACTGCGGC
GACGCCGACGTGGTCACACCGCCCGCTGCCTGCCGTGTCTGGGCAGACTTGTATGCTGCGCCCTTTGACTTGATCAAGGG
AGCCGGCCATGCCAGCCCTGTGGAGCAACCTGAAGCGGTCGCGCGCCTGATCACGCGCGCCGCGATGCAACCAAACGGAG
CCACGCACCATGAGTGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30742.11 Da        Isoelectric Point: 5.7143

>AT21541 WP_011484581.1 NC_007948:c3902534-3901698 [Polaromonas sp. JS666]
MSDNTAEENGNDKYIVPALERGLRLLGEFSRDSRTLSAPELARRLDLPRSTVFRLLNTLEAMGFIERTSGGSDYRLGMAV
LRLGFEYLSSLELTELGQPLLARLCDEIHYSCNLVVRDGRSIVYVAKVAPPTPFASSVRVGTRLPAHATVLGRVLLQDLT
LPELRAIYPEDHLEAFSASTPKTVLELFNLLEADRQRGYVMGEGYYEASISTIAAPVRDDSGRIIAALGTTIPSAHIETG
LVDDMVRHVRLSADELSRLLNYQPRSDSLNTVVALRLR

Download         Length: 837 bp

>AT21541 NC_007948:c3902534-3901698 [Polaromonas sp. JS666]
ATGAGTGACAACACCGCCGAAGAAAACGGCAACGACAAATACATCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCTCGG
AGAATTCAGCCGCGACAGCCGCACGCTGAGCGCGCCCGAACTGGCACGCCGACTTGACCTGCCGCGCTCCACGGTGTTTC
GCCTGCTCAACACGCTGGAGGCCATGGGCTTCATCGAGCGCACCAGCGGCGGCAGCGACTACCGCCTTGGCATGGCCGTG
CTGCGCCTGGGCTTTGAATACCTGTCCTCGCTGGAGCTCACCGAACTGGGTCAGCCATTGCTGGCGCGGCTGTGCGACGA
AATTCACTACTCGTGCAACCTGGTGGTGCGGGACGGGCGTTCGATCGTCTATGTGGCCAAGGTCGCGCCGCCGACGCCGT
TCGCCAGCTCGGTGCGCGTCGGCACGCGCCTGCCGGCCCACGCGACCGTTCTGGGCCGGGTACTGCTGCAGGACCTGACC
CTGCCCGAGTTGCGCGCGATCTACCCCGAGGATCACCTCGAAGCGTTTTCCGCCAGCACGCCCAAGACCGTGCTGGAACT
GTTCAACCTGCTGGAGGCGGACCGCCAGCGCGGCTACGTGATGGGCGAGGGCTATTACGAGGCCAGCATCTCCACCATTG
CGGCCCCGGTGCGCGACGACAGCGGCCGCATCATCGCCGCGCTGGGAACCACCATTCCCTCGGCCCACATCGAGACCGGG
CTGGTCGACGACATGGTGCGGCATGTGCGCCTGTCGGCCGACGAGTTGTCCCGCCTCCTGAATTACCAACCGCGCAGCGA
CAGCCTCAACACGGTCGTCGCCCTGCGCCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q126F1

Antitoxin

Source ID Structure
AlphaFold DB Q126F2

References