Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2356265..2356897 Replicon chromosome
Accession NZ_CP082837
Organism Sporolactobacillus terrae strain EFEL7003

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U1QR24
Locus tag K7399_RS11305 Protein ID WP_010025898.1
Coordinates 2356265..2356615 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U1QQW7
Locus tag K7399_RS11310 Protein ID WP_010025899.1
Coordinates 2356619..2356897 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7399_RS11285 (K7399_11250) 2353152..2353940 - 789 WP_037582118.1 RNA polymerase sigma factor SigB -
K7399_RS11290 (K7399_11255) 2353912..2354391 - 480 WP_028984087.1 anti-sigma B factor RsbW -
K7399_RS11295 (K7399_11260) 2354384..2354722 - 339 WP_028975631.1 STAS domain-containing protein -
K7399_RS11300 (K7399_11265) 2354786..2355784 - 999 WP_028984086.1 SpoIIE family protein phosphatase -
K7399_RS11305 (K7399_11270) 2356265..2356615 - 351 WP_010025898.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K7399_RS11310 (K7399_11275) 2356619..2356897 - 279 WP_010025899.1 ribbon-helix-helix protein, CopG family Antitoxin
K7399_RS11315 (K7399_11280) 2357058..2358248 - 1191 WP_028984085.1 alanine racemase -
K7399_RS11320 (K7399_11285) 2358486..2359496 - 1011 WP_128167161.1 outer membrane lipoprotein carrier protein LolA -
K7399_RS11325 (K7399_11290) 2359544..2361058 - 1515 WP_128167163.1 NAD(P)H-hydrate dehydratase -
K7399_RS11330 (K7399_11295) 2361114..2361476 - 363 WP_028984082.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.96 Da        Isoelectric Point: 6.4684

>T215401 WP_010025898.1 NZ_CP082837:c2356615-2356265 [Sporolactobacillus terrae]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHVEIDAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMGQVNKAIQISLSLIDF

Download         Length: 351 bp

>T215401 NZ_CP110674:c1355209-1354808 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10759.43 Da        Isoelectric Point: 6.4768

>AT215401 WP_010025899.1 NZ_CP082837:c2356897-2356619 [Sporolactobacillus terrae]
MSESKIKEIMLSLPQHLLNEIDGMASRDKMNRSEFLHRAIRLYLRERNRGYVREIMRQGYMEMAKINLNLASEAFLAEEE
AEITLERSVSGV

Download         Length: 279 bp

>AT215401 NZ_CP110674:c1355463-1355206 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1QR24

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1QQW7

References