Detailed information of TA system TA021538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 12259..12926
• Replicon: chromosome
• Accession: NC_007948
• Organism: Polaromonas sp. JS666

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q12HL2
• Locus tag: BPRO_RS00065
• Protein ID: WP_011480990.1
• Coordinates: 12504..12926 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BPRO_RS00060
• Protein ID: WP_041388105.1
• Coordinates: 12259..12507 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPRO_RS27870	7574..7912	-	339	WP_157045697.1	hypothetical protein	-
BPRO_RS00030	8122..8559	+	438	WP_157045698.1	hypothetical protein	-
BPRO_RS00035	8675..8914	+	240	WP_011480984.1	hypothetical protein	-
BPRO_RS00040	9217..9795	+	579	WP_011480985.1	NnrU family protein	-
BPRO_RS00045	9806..10417	+	612	WP_011480986.1	3'-5' exonuclease	-
BPRO_RS00050	10619..10816	+	198	WP_011480987.1	hypothetical protein	-
BPRO_RS00055	10874..12052	-	1179	WP_011480988.1	ATP-binding protein	-
BPRO_RS00060	12259..12507	+	249	WP_041388105.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BPRO_RS00065	12504..12926	+	423	WP_011480990.1	type II toxin-antitoxin system VapC family toxin	Toxin
BPRO_RS00070	13100..14320	+	1221	WP_011480991.1	Fic family protein	-
BPRO_RS00075	14503..15270	-	768	WP_157045866.1	DUF1749 domain-containing protein	-
BPRO_RS29360	15672..16328	+	657	WP_011480993.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15761.94 Da
• Isoelectric Point: 5.1968

>T21538 WP_011480990.1 NC_007948:12504-12926 [Polaromonas sp. JS666]
VSYLIDTNVISELVRPKPDPAVLHWFANTPDDALFLSALTLGEIRKGVEKLADTQRREELRLWLEHDLRDWFGPRILPIG
PDVADHWGRLLAQAGRPVPAIDSLLAATALHHDLRLVTRNTRDFDYAGLEVINPWETAAG

Nucleotide

• Length: 423 bp

>T21538 NC_007948:12504-12926 [Polaromonas sp. JS666]
GTGAGCTACCTGATTGACACCAACGTGATCTCGGAACTGGTTCGCCCGAAACCTGACCCCGCCGTGCTGCACTGGTTTGC
CAACACACCGGATGATGCCCTGTTTTTGAGCGCCTTGACGCTGGGCGAAATTCGCAAGGGCGTCGAGAAACTGGCCGACA
CCCAGCGCCGTGAAGAACTTCGCCTCTGGCTGGAGCATGACCTGCGCGACTGGTTTGGCCCGCGCATCCTGCCGATTGGC
CCGGACGTGGCCGACCACTGGGGCCGGCTGCTGGCGCAGGCGGGCCGTCCCGTGCCTGCCATCGACAGCCTGCTGGCTGC
TACAGCGCTGCATCACGACTTGCGGCTGGTCACCCGCAACACCAGAGATTTTGACTACGCGGGCCTGGAGGTTATCAATC
CGTGGGAGACGGCGGCGGGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9191.65 Da
• Isoelectric Point: 10.7969

>AT21538 WP_041388105.1 NC_007948:12259-12507 [Polaromonas sp. JS666]
MSTWQLQEAKGKFSEVVKRALSEGPQGITVRGEPVAVLISRAEYARLTHPKPRFVEFMRRSPMAGLELDTGRHTGLTREI
AL

Nucleotide

• Length: 249 bp

>AT21538 NC_007948:12259-12507 [Polaromonas sp. JS666]
ATGTCTACATGGCAACTGCAGGAAGCAAAGGGCAAATTCAGCGAGGTGGTGAAGCGCGCACTGAGCGAAGGGCCGCAAGG
CATTACGGTGCGCGGCGAGCCCGTGGCTGTGCTGATTTCGCGCGCGGAATACGCGCGCCTGACGCACCCCAAACCCAGGT
TTGTCGAGTTCATGCGCCGCTCTCCAATGGCCGGGCTGGAGCTGGATACCGGGCGACATACAGGTTTGACGCGCGAGATC
GCGCTGTGA

Structures

Toxin

• AlphaFold DB: Q12HL2