Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1952106..1952744 Replicon chromosome
Accession NZ_CP082835
Organism Escherichia coli strain 1613

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag K8O78_RS09630 Protein ID WP_000813794.1
Coordinates 1952106..1952282 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K8O78_RS09635 Protein ID WP_001270286.1
Coordinates 1952328..1952744 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O78_RS09610 (1947728) 1947728..1948900 - 1173 WP_001236316.1 BenE family transporter YdcO -
K8O78_RS09615 (1948992) 1948992..1949528 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
K8O78_RS09620 (1949601) 1949601..1951562 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
K8O78_RS09625 (1951654) 1951654..1951884 - 231 WP_000494244.1 YncJ family protein -
K8O78_RS09630 (1952106) 1952106..1952282 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
K8O78_RS09635 (1952328) 1952328..1952744 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
K8O78_RS09640 (1952823) 1952823..1954229 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
K8O78_RS09645 (1954474) 1954474..1955619 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
K8O78_RS09650 (1955637) 1955637..1956650 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
K8O78_RS09655 (1956651) 1956651..1957592 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T215372 WP_000813794.1 NZ_CP082835:1952106-1952282 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T215372 NZ_CP110664:1503096-1503347 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT215372 WP_001270286.1 NZ_CP082835:1952328-1952744 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT215372 NZ_CP110664:1503344-1503604 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References