Detailed information of TA system TA215366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1270239..1270717
• Replicon: chromosome
• Accession: NZ_CP082835
• Organism: Escherichia coli strain 1613

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: K8O78_RS05860
• Protein ID: WP_001303876.1
• Coordinates: 1270239..1270526 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: K8O78_RS05865
• Protein ID: WP_000536233.1
• Coordinates: 1270526..1270717 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O78_RS05825 (1265388)	1265388..1267859	-	2472	WP_000034474.1	exonuclease	-
K8O78_RS05830 (1267953)	1267953..1268144	-	192	WP_001098307.1	DUF1482 family protein	-
K8O78_RS05835 (1268141)	1268141..1268329	-	189	WP_000413705.1	cell division inhibition protein DicB	-
K8O78_RS05840 (1268903)	1268903..1269088	+	186	WP_001133046.1	hypothetical protein	-
K8O78_RS05845 (1269275)	1269275..1269664	-	390	WP_000394511.1	hypothetical protein	-
K8O78_RS05850 (1269676)	1269676..1269804	-	129	WP_000344963.1	protein YdfB	-
K8O78_RS05855 (1269806)	1269806..1269961	-	156	WP_000379575.1	DUF1391 family protein	-
K8O78_RS05860 (1270239)	1270239..1270526	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8O78_RS05865 (1270526)	1270526..1270717	-	192	WP_000536233.1	hypothetical protein	Antitoxin
K8O78_RS05870 (1270745)	1270745..1271146	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
K8O78_RS05875 (1271255)	1271255..1271527	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
K8O78_RS05880 (1271511)	1271511..1271936	+	426	WP_000693855.1	toxin YdaT family protein	-
K8O78_RS05885 (1272143)	1272143..1272598	-	456	WP_000273724.1	hypothetical protein	-
K8O78_RS05890 (1272677)	1272677..1273768	+	1092	WP_001205823.1	hypothetical protein	-
K8O78_RS05895 (1273775)	1273775..1274521	+	747	WP_000788751.1	ATP-binding protein	-
K8O78_RS05900 (1274543)	1274543..1275313	+	771	WP_000450992.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T215366 WP_001303876.1 NZ_CP082835:c1270526-1270239 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T215366 NZ_CP110661:4285709-4286092 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT215366 WP_000536233.1 NZ_CP082835:c1270717-1270526 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT215366 NZ_CP110661:4285467-4285709 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA