Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1157139..1157974 Replicon chromosome
Accession NZ_CP082835
Organism Escherichia coli strain 1613

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag K8O78_RS05360 Protein ID WP_032107687.1
Coordinates 1157597..1157974 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K8O78_RS05355 Protein ID WP_033805992.1
Coordinates 1157139..1157507 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O78_RS05305 (1152710) 1152710..1152883 + 174 WP_001370911.1 hypothetical protein -
K8O78_RS05310 (1153008) 1153008..1153547 + 540 WP_001104020.1 DUF4339 domain-containing protein -
K8O78_RS05315 (1153817) 1153817..1154230 + 414 WP_000789535.1 hypothetical protein -
K8O78_RS05320 (1154370) 1154370..1154509 - 140 Protein_1039 hypothetical protein -
K8O78_RS05325 (1154479) 1154479..1154551 + 73 Protein_1040 hypothetical protein -
K8O78_RS05330 (1154641) 1154641..1155459 + 819 WP_033805991.1 DUF932 domain-containing protein -
K8O78_RS05335 (1155459) 1155459..1155632 + 174 WP_001684385.1 hypothetical protein -
K8O78_RS05340 (1155798) 1155798..1156277 + 480 WP_001684386.1 antirestriction protein -
K8O78_RS05345 (1156293) 1156293..1156769 + 477 WP_001186745.1 RadC family protein -
K8O78_RS05350 (1156838) 1156838..1157059 + 222 WP_001684649.1 DUF987 domain-containing protein -
K8O78_RS05355 (1157139) 1157139..1157507 + 369 WP_033805992.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8O78_RS05360 (1157597) 1157597..1157974 + 378 WP_032107687.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
K8O78_RS05365 (1157971) 1157971..1158459 + 489 WP_001684187.1 DUF5983 family protein -
K8O78_RS05370 (1158471) 1158471..1158647 + 177 WP_001684188.1 DUF957 domain-containing protein -
K8O78_RS05375 (1158753) 1158753..1159595 + 843 WP_001684189.1 DUF4942 domain-containing protein -
K8O78_RS05385 (1160086) 1160086..1160304 - 219 WP_001040187.1 translation initiation factor IF-1 -
K8O78_RS05390 (1160589) 1160589..1161293 - 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13903.98 Da        Isoelectric Point: 7.7785

>T215365 WP_032107687.1 NZ_CP082835:1157597-1157974 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTCSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGVKQ

Download         Length: 378 bp

>T215365 NZ_CP110661:c3879038-3878670 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13578.33 Da        Isoelectric Point: 6.7384

>AT215365 WP_033805992.1 NZ_CP082835:1157139-1157507 [Escherichia coli]
VSDTLHETNHPDGNNNSPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADVYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSKTKK

Download         Length: 369 bp

>AT215365 NZ_CP110661:c3879256-3879035 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References