215359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 3821..4286 Replicon plasmid pCRTS
Accession NZ_CP082834
Organism Citrobacter rodentium NBRC 105723 = DSM 16636

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag K7R23_RS25545 Protein ID WP_001230707.1
Coordinates 3821..4072 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag K7R23_RS25550 Protein ID WP_000801440.1
Coordinates 4059..4286 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7R23_RS25520 (K7R23_25330) 1129..1380 + 252 WP_000121743.1 plasmid stabilization protein -
K7R23_RS25525 (K7R23_25335) 1370..1651 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
K7R23_RS25530 (K7R23_25340) 1675..2024 + 350 Protein_2 DNA-binding protein -
K7R23_RS25535 (K7R23_25345) 2662..3177 + 516 WP_001025397.1 J domain-containing protein -
K7R23_RS25540 (K7R23_25350) 3282..3824 + 543 WP_012908950.1 hypothetical protein -
K7R23_RS25545 (K7R23_25355) 3821..4072 + 252 WP_001230707.1 hypothetical protein Toxin
K7R23_RS25550 (K7R23_25360) 4059..4286 + 228 WP_000801440.1 hypothetical protein Antitoxin
K7R23_RS25555 (K7R23_25365) 4740..5039 + 300 WP_000650311.1 hypothetical protein -
K7R23_RS25560 (K7R23_25370) 5131..5481 + 351 WP_000854261.1 hypothetical protein -
K7R23_RS25565 (K7R23_25375) 5787..6035 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
K7R23_RS25570 (K7R23_25380) 6032..6379 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
K7R23_RS25575 (K7R23_25385) 6743..7246 + 504 WP_000781818.1 DNA distortion polypeptide 1 -
K7R23_RS25580 (K7R23_25390) 7250..8479 + 1230 WP_000539545.1 DNA relaxase/nickase TaxC -
K7R23_RS25585 (K7R23_25395) 8556..8822 + 267 WP_000160396.1 hypothetical protein -
K7R23_RS25590 (K7R23_25400) 8827..9060 + 234 WP_000121162.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39262 39262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T215359 WP_001230707.1 NZ_CP082834:3821-4072 [Citrobacter rodentium NBRC 105723 = DSM 16636]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T215359 NZ_CP110658:84382-85707 [Salmonella enterica subsp. enterica]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT215359 WP_000801440.1 NZ_CP082834:4059-4286 [Citrobacter rodentium NBRC 105723 = DSM 16636]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT215359 NZ_CP110658:84084-84377 [Salmonella enterica subsp. enterica]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References