Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1129..1651 Replicon plasmid pCRTS
Accession NZ_CP082834
Organism Citrobacter rodentium NBRC 105723 = DSM 16636

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag K7R23_RS25525 Protein ID WP_000220561.1
Coordinates 1370..1651 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag K7R23_RS25520 Protein ID WP_000121743.1
Coordinates 1129..1380 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7R23_RS25520 (K7R23_25330) 1129..1380 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
K7R23_RS25525 (K7R23_25335) 1370..1651 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7R23_RS25530 (K7R23_25340) 1675..2024 + 350 Protein_2 DNA-binding protein -
K7R23_RS25535 (K7R23_25345) 2662..3177 + 516 WP_001025397.1 J domain-containing protein -
K7R23_RS25540 (K7R23_25350) 3282..3824 + 543 WP_012908950.1 hypothetical protein -
K7R23_RS25545 (K7R23_25355) 3821..4072 + 252 WP_001230707.1 hypothetical protein -
K7R23_RS25550 (K7R23_25360) 4059..4286 + 228 WP_000801440.1 hypothetical protein -
K7R23_RS25555 (K7R23_25365) 4740..5039 + 300 WP_000650311.1 hypothetical protein -
K7R23_RS25560 (K7R23_25370) 5131..5481 + 351 WP_000854261.1 hypothetical protein -
K7R23_RS25565 (K7R23_25375) 5787..6035 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
K7R23_RS25570 (K7R23_25380) 6032..6379 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39262 39262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T215358 WP_000220561.1 NZ_CP082834:1370-1651 [Citrobacter rodentium NBRC 105723 = DSM 16636]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T215358 NZ_CP110657:c4597007-4596723 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT215358 WP_000121743.1 NZ_CP082834:1129-1380 [Citrobacter rodentium NBRC 105723 = DSM 16636]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT215358 NZ_CP110657:c4597245-4596997 [Salmonella enterica subsp. enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References