Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 950914..951568 Replicon chromosome
Accession NZ_CP082831
Organism Escherichia coli strain SCAID WND1-2021 (1/128)

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag K8B75_RS04655 Protein ID WP_000244765.1
Coordinates 951161..951568 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag K8B75_RS04650 Protein ID WP_000354050.1
Coordinates 950914..951180 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B75_RS04630 (947002) 947002..948435 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
K8B75_RS04635 (948480) 948480..948791 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
K8B75_RS04640 (948955) 948955..949614 + 660 WP_000250275.1 hemolysin III family protein -
K8B75_RS04645 (949691) 949691..950671 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
K8B75_RS04650 (950914) 950914..951180 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
K8B75_RS04655 (951161) 951161..951568 + 408 WP_000244765.1 protein YgfX Toxin
K8B75_RS04660 (951608) 951608..952129 - 522 WP_001055874.1 flavodoxin FldB -
K8B75_RS04665 (952241) 952241..953137 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
K8B75_RS04670 (953162) 953162..953872 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K8B75_RS04675 (953878) 953878..955611 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T215307 WP_000244765.1 NZ_CP082831:951161-951568 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T215307 NZ_CP110629:c4047314-4047063 [Marinimicrobium sp. C6131]
ATGGACATTATCAATTTCTCTGCCTTCCGGGAAAAATTGGCGAGCTTTATGGATCGGGTCAATGACGATCACGCACCCGT
AATCATTCGCCGCTCAAAGAACCGGTCAGCAGTACTGATGAGCCTGGAAGACTTCCAGTCCTATGAGGAAACCAGCTACC
TCCTGTCTACGCCAGCCAATGCCCGGGCGCTTCAAACCTCTTTGGAAGAGGCCGAGCGCGGCGACATCGTGCAGAGGAAT
CTGGTTGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT215307 WP_000354050.1 NZ_CP082831:950914-951180 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215307 NZ_CP110629:c4047066-4046797 [Marinimicrobium sp. C6131]
ATGATTTTGGCATGGACATCGACTGCCTGGAGTGAGTACGAATACTGGCAGGGAACGGATAAGAAAACGGTAAAACGTAT
CAATAAGCTAATCCAGGAGACGATGCGCACCCCTTTTGACGGCAGCGGTAAACCTGAGCCCCTAAAACACGGACTGAAAG
GTTACTGGTCCCGACGTATCGACCGGGAGCACCGACTGGTTTACAAGCTCAAAGGCGAAGGCCCCGACGCCACTTTGCTT
ATCATTCAGTGCCGTTTCCATTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References