Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 805823..806657 | Replicon | chromosome |
| Accession | NZ_CP082831 | ||
| Organism | Escherichia coli strain SCAID WND1-2021 (1/128) | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | K8B75_RS03900 | Protein ID | WP_000854690.1 |
| Coordinates | 805823..806200 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | K8B75_RS03905 | Protein ID | WP_001305076.1 |
| Coordinates | 806289..806657 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B75_RS03870 (802217) | 802217..802387 | - | 171 | Protein_766 | IS110 family transposase | - |
| K8B75_RS03875 (802804) | 802804..803737 | - | 934 | Protein_767 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| K8B75_RS03880 (803730) | 803730..804125 | - | 396 | WP_000208384.1 | DUF6088 family protein | - |
| K8B75_RS03885 (804194) | 804194..805039 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| K8B75_RS03890 (805124) | 805124..805321 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| K8B75_RS03895 (805338) | 805338..805826 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| K8B75_RS03900 (805823) | 805823..806200 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| K8B75_RS03905 (806289) | 806289..806657 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K8B75_RS03910 (806707) | 806707..807351 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| K8B75_RS03915 (807370) | 807370..807591 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| K8B75_RS03920 (807654) | 807654..808130 | - | 477 | WP_001186726.1 | RadC family protein | - |
| K8B75_RS03925 (808146) | 808146..808631 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| K8B75_RS03930 (808686) | 808686..809504 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| K8B75_RS03935 (809605) | 809605..809838 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| K8B75_RS03940 (809917) | 809917..810372 | - | 456 | WP_000581502.1 | IrmA family protein | - |
| K8B75_RS03945 (810448) | 810448..811574 | - | 1127 | Protein_781 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF | 784206..808631 | 24425 | |
| - | flank | IS/Tn | - | - | 802217..802372 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T215306 WP_000854690.1 NZ_CP082831:c806200-805823 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T215306 NZ_CP110629:c4047066-4046797 [Marinimicrobium sp. C6131]
ATGATTTTGGCATGGACATCGACTGCCTGGAGTGAGTACGAATACTGGCAGGGAACGGATAAGAAAACGGTAAAACGTAT
CAATAAGCTAATCCAGGAGACGATGCGCACCCCTTTTGACGGCAGCGGTAAACCTGAGCCCCTAAAACACGGACTGAAAG
GTTACTGGTCCCGACGTATCGACCGGGAGCACCGACTGGTTTACAAGCTCAAAGGCGAAGGCCCCGACGCCACTTTGCTT
ATCATTCAGTGCCGTTTCCATTACGAATAA
ATGATTTTGGCATGGACATCGACTGCCTGGAGTGAGTACGAATACTGGCAGGGAACGGATAAGAAAACGGTAAAACGTAT
CAATAAGCTAATCCAGGAGACGATGCGCACCCCTTTTGACGGCAGCGGTAAACCTGAGCCCCTAAAACACGGACTGAAAG
GTTACTGGTCCCGACGTATCGACCGGGAGCACCGACTGGTTTACAAGCTCAAAGGCGAAGGCCCCGACGCCACTTTGCTT
ATCATTCAGTGCCGTTTCCATTACGAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT215306 WP_001305076.1 NZ_CP082831:c806657-806289 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT215306 NZ_CP110629:c4047314-4047063 [Marinimicrobium sp. C6131]
ATGGACATTATCAATTTCTCTGCCTTCCGGGAAAAATTGGCGAGCTTTATGGATCGGGTCAATGACGATCACGCACCCGT
AATCATTCGCCGCTCAAAGAACCGGTCAGCAGTACTGATGAGCCTGGAAGACTTCCAGTCCTATGAGGAAACCAGCTACC
TCCTGTCTACGCCAGCCAATGCCCGGGCGCTTCAAACCTCTTTGGAAGAGGCCGAGCGCGGCGACATCGTGCAGAGGAAT
CTGGTTGAATGA
ATGGACATTATCAATTTCTCTGCCTTCCGGGAAAAATTGGCGAGCTTTATGGATCGGGTCAATGACGATCACGCACCCGT
AATCATTCGCCGCTCAAAGAACCGGTCAGCAGTACTGATGAGCCTGGAAGACTTCCAGTCCTATGAGGAAACCAGCTACC
TCCTGTCTACGCCAGCCAATGCCCGGGCGCTTCAAACCTCTTTGGAAGAGGCCGAGCGCGGCGACATCGTGCAGAGGAAT
CTGGTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|