Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 848876..849710 Replicon chromosome
Accession NZ_CP082827
Organism Escherichia coli strain SCAID WND2-2021 (3/145)

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag K8B73_RS04070 Protein ID WP_000854689.1
Coordinates 848876..849253 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K8B73_RS04075 Protein ID WP_223107141.1
Coordinates 849330..849710 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B73_RS04030 (844085) 844085..844564 + 480 Protein_795 IS3 family transposase -
K8B73_RS04035 (844605) 844605..844907 - 303 Protein_796 IS21 family transposase -
K8B73_RS04040 (845256) 845256..845426 - 171 Protein_797 IS110 family transposase -
K8B73_RS04045 (845897) 845897..846790 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
K8B73_RS04050 (846783) 846783..847178 - 396 WP_000208383.1 DUF6088 family protein -
K8B73_RS04055 (847247) 847247..848092 - 846 WP_001529401.1 DUF4942 domain-containing protein -
K8B73_RS04060 (848177) 848177..848374 - 198 WP_000839293.1 DUF957 domain-containing protein -
K8B73_RS04065 (848391) 848391..848879 - 489 WP_000761699.1 DUF5983 family protein -
K8B73_RS04070 (848876) 848876..849253 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
K8B73_RS04075 (849330) 849330..849710 - 381 WP_223107141.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B73_RS04080 (849760) 849760..850404 - 645 WP_021566525.1 hypothetical protein -
K8B73_RS04085 (850423) 850423..850644 - 222 WP_000692300.1 DUF987 domain-containing protein -
K8B73_RS04090 (850707) 850707..851183 - 477 WP_001186774.1 RadC family protein -
K8B73_RS04095 (851198) 851198..851683 - 486 WP_000849565.1 antirestriction protein -
K8B73_RS04100 (851738) 851738..852556 - 819 WP_001234620.1 DUF932 domain-containing protein -
K8B73_RS04105 (852657) 852657..852890 - 234 WP_001119727.1 DUF905 family protein -
K8B73_RS04110 (852969) 852969..853424 - 456 WP_064772576.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T215271 WP_000854689.1 NZ_CP082827:c849253-848876 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T215271 NZ_CP110619:2322630-2323040 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13867.68 Da        Isoelectric Point: 4.7959

>AT215271 WP_223107141.1 NZ_CP082827:c849710-849330 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVCLAVYPATETESNPPE

Download         Length: 381 bp

>AT215271 NZ_CP110619:2322404-2322637 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References