Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 5775539..5776179 | Replicon | chromosome |
| Accession | NZ_CP082823 | ||
| Organism | Pseudomonas aeruginosa strain SCAID TST-2021 (7/157) | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K8B71_RS27940 | Protein ID | WP_003134109.1 |
| Coordinates | 5775539..5775949 (-) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | K8B71_RS27945 | Protein ID | WP_031634724.1 |
| Coordinates | 5775949..5776179 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B71_RS27895 (K8B71_27895) | 5771821..5772234 | - | 414 | WP_153570846.1 | hypothetical protein | - |
| K8B71_RS27900 (K8B71_27900) | 5772245..5772385 | + | 141 | WP_153549538.1 | hypothetical protein | - |
| K8B71_RS27905 (K8B71_27905) | 5772542..5773270 | + | 729 | WP_023094843.1 | TIGR03761 family integrating conjugative element protein | - |
| K8B71_RS27910 (K8B71_27910) | 5773276..5773809 | + | 534 | WP_003134105.1 | DUF3158 family protein | - |
| K8B71_RS27915 (K8B71_27915) | 5773823..5774311 | + | 489 | WP_003134107.1 | single-stranded DNA-binding protein | - |
| K8B71_RS27920 (K8B71_27920) | 5774415..5774609 | + | 195 | WP_031632157.1 | hypothetical protein | - |
| K8B71_RS27925 (K8B71_27925) | 5774861..5775028 | + | 168 | WP_128729268.1 | CrpP family ICE-associated protein | - |
| K8B71_RS27930 (K8B71_27930) | 5775094..5775312 | - | 219 | WP_023094844.1 | hypothetical protein | - |
| K8B71_RS27935 (K8B71_27935) | 5775329..5775523 | - | 195 | WP_023094845.1 | hypothetical protein | - |
| K8B71_RS27940 (K8B71_27940) | 5775539..5775949 | - | 411 | WP_003134109.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| K8B71_RS27945 (K8B71_27945) | 5775949..5776179 | - | 231 | WP_031634724.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| K8B71_RS27950 (K8B71_27950) | 5776497..5778416 | + | 1920 | WP_003134111.1 | type I DNA topoisomerase | - |
| K8B71_RS27955 (K8B71_27955) | 5778598..5779176 | + | 579 | WP_023094847.1 | hypothetical protein | - |
| K8B71_RS27960 (K8B71_27960) | 5779293..5779898 | - | 606 | WP_023094848.1 | LysE family translocator | - |
| K8B71_RS27965 (K8B71_27965) | 5780020..5780889 | + | 870 | WP_023094849.1 | LysR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | katA | 5758230..5876836 | 118606 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 15452.78 Da Isoelectric Point: 7.3233
>T215228 WP_003134109.1 NZ_CP082823:c5775949-5775539 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV
Download Length: 411 bp
>T215228 NZ_CP110611:985212-985391 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8420.29 Da Isoelectric Point: 4.2821
>AT215228 WP_031634724.1 NZ_CP082823:c5776179-5775949 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF
Download Length: 231 bp
>AT215228 NZ_CP110611:984589-985188 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|