Detailed information of TA system TA215223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3866865..3868086
• Replicon: chromosome
• Accession: NZ_CP082823
• Organism: Pseudomonas aeruginosa strain SCAID TST-2021 (7/157)

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: K8B71_RS18475
• Protein ID: WP_003110488.1
• Coordinates: 3867508..3868086 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K8B71_RS18470
• Protein ID: WP_003132728.1
• Coordinates: 3866865..3867419 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T215223 WP_003110488.1 NZ_CP082823:3867508-3868086 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T215223 NZ_CP110535:3632120-3632383 [Halomonas sp. BDJS001]
GTGACATGGAAGTTGGCTTACACCAAGCAAGCTCAGAAAGACGCAAAGAAACTTGTTTCCAGCGGCCTCAAGCCAAAAGC
CCAGGAATTGTTGGCACTTATTGCAGAAGATCCCTACCGCAAGCCGCCTCCGTTTGAGAAGCTCATTGGTGATCTTGCGG
GAGCCTATTCACGACGCATCAACATTCAACATCGTCTGGTTTACCAAGTGCTCGAAGACGAGCGAGTGGTGAAAGTTTTG
AGGCTATGGAGCCACTACGAATAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20470.63 Da
• Isoelectric Point: 8.1590

>AT215223 WP_003132728.1 NZ_CP082823:3866865-3867419 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT215223 NZ_CP110535:3631881-3632123 [Halomonas sp. BDJS001]
ATGACCGGAATTACAGCCACTGAGGCGCGCAGCAATCTTTACCGGTTGATTGATGAGACTGCCGAGTCTCACCAACCCAT
CGTCATCATGGGGAAGCGTAACAGTGCCGTCTTGGTATCCGAAGAAGATTGGTCGGCCATTCAGGAAACGCTTTACCTGC
TTTCTGTACCCGGCATGCGGGAATCGATTAGTGAAGGGATGAATACCCCTGTAGCTGAATGCGATGAGGAGCTGGACTGG
TGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4