215222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1926912..1928420 Replicon chromosome
Accession NZ_CP082823
Organism Pseudomonas aeruginosa strain SCAID TST-2021 (7/157)

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag K8B71_RS09070 Protein ID WP_003119682.1
Coordinates 1926912..1927499 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag K8B71_RS09075 Protein ID WP_003091607.1
Coordinates 1927566..1928420 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B71_RS09065 (K8B71_09065) 1923167..1926646 - 3480 WP_004363078.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
K8B71_RS09070 (K8B71_09070) 1926912..1927499 + 588 WP_003119682.1 GNAT family protein Toxin
K8B71_RS09075 (K8B71_09075) 1927566..1928420 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
K8B71_RS09080 (K8B71_09080) 1928517..1930682 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
K8B71_RS09085 (K8B71_09085) 1930857..1932731 + 1875 WP_003091605.1 MFS transporter -
K8B71_RS09090 (K8B71_09090) 1932792..1933001 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T215222 WP_003119682.1 NZ_CP082823:1926912-1927499 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T215222 NZ_CP110535:c3164278-3163760 [Halomonas sp. BDJS001]
ATGATAGTGCTGCCGGAGCTGAAAACTCAGGCATACCGTGTACATGTTCCGCGCTGGGCATTTTCGCCTACTAGTGGGGC
TGGAGCGAGAGAGCATGGAGGAAGGCTAAACCGAGTTGGCGTCGATGCATTATACTTGTCGCTAGAGGAGCAAACAGCGT
TAGCGGAGTACAAACAGCTTTCTGCATTAATGCCACCTGGGCTGATTGTTAGCTATACGGTCAGCGTGACGACTATTATC
GATTTTCGATCAGGCTATAACTCGAAATGGGATAGCCTCTGGCAAGAGCTTAACTGTGACTGGCGTAAGTATTGGTTTAA
TCAGCGTATTGAGCCGCCTAGCTGGTTACTAGGCGATATGGCGTTGGAGCAAGGTGTTAAAGGAATACTGTTTCCTTCTT
TGGCACATGCTTCAGGTACTAATCTTGTCCTCTATACCGAAACGTTAACAGAATACGATAGTCTAGAGGTCTATGATCCG
AAAGGTGATTTGCCCCACAACGCGCGCTCCTGGCAGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT215222 WP_003091607.1 NZ_CP082823:1927566-1928420 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT215222 NZ_CP110535:c3164706-3164275 [Halomonas sp. BDJS001]
ATGGCAATTGACACTGTAAAAGAATCCCTTAATGAGTCATCCGGGTATCTGGTGCCTGATTCGTTTGAGCGGTTTTTGGC
TGATTTGAAGGGCGCTGCTCGAGAAGATCGCCACCCACTGATTAACCCGAAGTTGTTTGCCAGTGCATTGAGCATCGATA
TCCAAACGCTTGCTAGTCAAGCGCACGTGCATCGTACGACGATCTCACGTGCTCAGGGGGCAGAAAAACTTCAACGTTAT
CTTCGTGATGCACTTCGTGTGCTCGGTGCAGCGGCGGATATTAATGGTGACTTTCATGACGCTCTGTTTTGGTTTCGCAA
CGAGCCGCTTAGCGCATTTGACTATAAAACACCCGAGCAACTCGTAAGTGAAGGGCGCGCAGAAGACTTGTTGCGCTATG
TTCAGGCGCTGCAAGCAGGTGTAGCGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References