Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1707705..1709400 | Replicon | chromosome |
| Accession | NZ_CP082822 | ||
| Organism | Pseudomonas aeruginosa strain SCAID WND1-2021 (9/195) | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | K8B69_RS08080 | Protein ID | WP_003112901.1 |
| Coordinates | 1707705..1708574 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | K8B69_RS08085 | Protein ID | WP_003112902.1 |
| Coordinates | 1708567..1709400 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B69_RS08055 (K8B69_08055) | 1703713..1704564 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| K8B69_RS08060 (K8B69_08060) | 1704605..1705612 | + | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| K8B69_RS08065 (K8B69_08065) | 1705609..1706385 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| K8B69_RS08070 (K8B69_08070) | 1706391..1707152 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| K8B69_RS08075 (K8B69_08075) | 1707166..1707696 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| K8B69_RS08080 (K8B69_08080) | 1707705..1708574 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| K8B69_RS08085 (K8B69_08085) | 1708567..1709400 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| K8B69_RS08090 (K8B69_08090) | 1709387..1710184 | + | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| K8B69_RS08095 (K8B69_08095) | 1710177..1711859 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| K8B69_RS08100 (K8B69_08100) | 1711870..1712673 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| K8B69_RS08105 (K8B69_08105) | 1712685..1714169 | + | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T215212 WP_003112901.1 NZ_CP082822:1707705-1708574 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T215212 NZ_CP110534:927808-928176 [Enterobacter roggenkampii]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGCTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAGCAGCACTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGATCGCAGAGGATTT
AGCTCACAGGGACAAGTGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGTGGATTAACGAACAGTTG
TCCTTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGACATGCTTATCACCCGTGGTTGTCTGGCAAATGCTGCTTGC
TCGACTACTTGAGCAGCACTATGGCCTGACCTTAAATGACACGCCGTTCAGCGATGAGGCTGTTATTAAAAGACATATCG
AAGCTGGTATCACGCTTGTCGATGCCGTTAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGATCGCAGAGGATTT
AGCTCACAGGGACAAGTGCCATATTTGACCGTGACAGATATCCTTCATGCCAGGAGAGCATGTGGATTAACGAACAGTTG
TCCTTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT215212 WP_003112902.1 NZ_CP082822:1708567-1709400 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
>AT215212 NZ_CP110534:927423-927773 [Enterobacter roggenkampii]
ATGTCGAGTAAGACACTCACTGTGAATGATGATACAGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCACGTCTGGTCCAGGAAGGTAACCGCCTACATTACCTGTCTGACCGCGCCAGCATAACAGGTCAGTTCAATAAAG
CGGATTTGCTCCATCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCAGCGAACTGAAT
CCCCGACACCAGCATAGCGTCACCCTCTATGCAAAGGGGTTGACCTGTGAAGTTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA
ATGTCGAGTAAGACACTCACTGTGAATGATGATACAGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCACGTCTGGTCCAGGAAGGTAACCGCCTACATTACCTGTCTGACCGCGCCAGCATAACAGGTCAGTTCAATAAAG
CGGATTTGCTCCATCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCAGCGAACTGAAT
CCCCGACACCAGCATAGCGTCACCCTCTATGCAAAGGGGTTGACCTGTGAAGTTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|