Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5723617..5724257 Replicon chromosome
Accession NZ_CP082821
Organism Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222)

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8B72_RS27630 Protein ID WP_003134109.1
Coordinates 5723617..5724027 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8B72_RS27635 Protein ID WP_031634724.1
Coordinates 5724027..5724257 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B72_RS27585 (K8B72_27585) 5719899..5720312 - 414 WP_153570846.1 hypothetical protein -
K8B72_RS27590 (K8B72_27590) 5720323..5720463 + 141 WP_153549538.1 hypothetical protein -
K8B72_RS27595 (K8B72_27595) 5720620..5721348 + 729 WP_023094843.1 TIGR03761 family integrating conjugative element protein -
K8B72_RS27600 (K8B72_27600) 5721354..5721887 + 534 WP_003134105.1 DUF3158 family protein -
K8B72_RS27605 (K8B72_27605) 5721901..5722389 + 489 WP_003134107.1 single-stranded DNA-binding protein -
K8B72_RS27610 (K8B72_27610) 5722493..5722687 + 195 WP_031632157.1 hypothetical protein -
K8B72_RS27615 (K8B72_27615) 5722939..5723106 + 168 Protein_5469 CrpP family protein -
K8B72_RS27620 (K8B72_27620) 5723172..5723390 - 219 WP_023094844.1 hypothetical protein -
K8B72_RS27625 (K8B72_27625) 5723407..5723601 - 195 WP_023094845.1 hypothetical protein -
K8B72_RS27630 (K8B72_27630) 5723617..5724027 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
K8B72_RS27635 (K8B72_27635) 5724027..5724257 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8B72_RS27640 (K8B72_27640) 5724575..5726494 + 1920 WP_003134111.1 type I DNA topoisomerase -
K8B72_RS27645 (K8B72_27645) 5726676..5727254 + 579 WP_023094847.1 hypothetical protein -
K8B72_RS27650 (K8B72_27650) 5727371..5727976 - 606 WP_023094848.1 LysE family translocator -
K8B72_RS27655 (K8B72_27655) 5728098..5728967 + 870 WP_023094849.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 5707670..5826261 118591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T215208 WP_003134109.1 NZ_CP082821:c5724027-5723617 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T215208 NZ_CP110533:c4637653-4637282 [Enterobacter quasiroggenkampii]
ATGGAACACATGGCGGTTTTTGATACCAATATCCTGATCGACCTTTTCAACAATCGCGTCGAGGCAGCAAATACGATCGA
AAACACAGCATCGCACCGGTCAATCAGTCTAATCACATGGATGGAAGTCATGGTAGGGGCGCGCAAACATGGCCACGAAG
CGAAAACCGCGGCGGTAATGGGCGCATTTGAGGTTATCGATGTAACCCGAGAGATCGCAGAAAGAAGCGTCGTGCTCCGT
GAGAAGCATGGCATGAAACTGCCGGATGCCATTATTTTAGCGACTGCCCAAAGCAGAAATTGCCCGTTAGTCACCCGGAA
TACCAAAGACTTTCAGGGGATTGCCGGGGTGGTTTTACCTTATCAATTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT215208 WP_031634724.1 NZ_CP082821:c5724257-5724027 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT215208 NZ_CP110533:c4637898-4637656 [Enterobacter quasiroggenkampii]
ATGAGTTTACTGGCGGAGCTTAACATGGGCAGAATCCTGATCGATTTGTCGGATGACGTTATTCAACGTCTCGATAACCT
TAAACAGCTGCGTAACCAACCTCGTGCCGAATTACTGCGTGAAGCAATTGAGCAGTATCTCGATCAGCAAAGCTCGTCCG
TTATCCGTGATGCGCTTGGTCTTTGGGGTAACCAGCAAGAAGATGGTTTAGAGTATGAGCGCAAGCTGCGTGAGGAGTGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References