215207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5334772..5335380 Replicon chromosome
Accession NZ_CP082821
Organism Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222)

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag K8B72_RS25780 Protein ID WP_003114156.1
Coordinates 5334772..5335119 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag K8B72_RS25785 Protein ID WP_003114155.1
Coordinates 5335129..5335380 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B72_RS25745 (K8B72_25745) 5330953..5331129 + 177 WP_023127210.1 hypothetical protein -
K8B72_RS25750 (K8B72_25750) 5331126..5331752 + 627 WP_023127428.1 hypothetical protein -
K8B72_RS25755 (K8B72_25755) 5331749..5332606 + 858 WP_023127429.1 DNA adenine methylase -
K8B72_RS25760 (K8B72_25760) 5332594..5332836 + 243 WP_023127213.1 hypothetical protein -
K8B72_RS25765 (K8B72_25765) 5332829..5333032 + 204 WP_031759157.1 hypothetical protein -
K8B72_RS25770 (K8B72_25770) 5333025..5333228 + 204 WP_003098423.1 AlpA family phage regulatory protein -
K8B72_RS25775 (K8B72_25775) 5333235..5334437 - 1203 WP_023127430.1 integrase family protein -
K8B72_RS25780 (K8B72_25780) 5334772..5335119 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8B72_RS25785 (K8B72_25785) 5335129..5335380 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8B72_RS25790 (K8B72_25790) 5335594..5336576 - 983 Protein_5112 tyrosine-type recombinase/integrase -
K8B72_RS25795 (K8B72_25795) 5336576..5337868 - 1293 WP_003134394.1 hypothetical protein -
K8B72_RS25800 (K8B72_25800) 5338098..5339381 - 1284 WP_023127773.1 zonular occludens toxin domain-containing protein -
K8B72_RS25805 (K8B72_25805) 5339385..5339741 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5298761..5360739 61978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T215207 WP_003114156.1 NZ_CP082821:c5335119-5334772 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T215207 NZ_CP110533:c3862504-3862094 [Enterobacter quasiroggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTGTTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTATTACTCTCGTTTGTCGTGTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATCAAGCTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT215207 WP_003114155.1 NZ_CP082821:c5335380-5335129 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT215207 NZ_CP110533:c3862751-3862485 [Enterobacter quasiroggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References